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Neuregulin-1 antibody [k1G13]

Anti-Neuregulin-1 antibody [k1G13] used in Western Blot (WB). GTX50038

Cat No. GTX50038

Host

Mouse

Clonality

Monoclonal

Clone Name

k1G13

Isotype

IgG1

Application

WB, ELISA

Reactivity

Human
Package
100 μl ($319)

APPLICATION

Application Note

We recommend the following starting dilutions:
Western Blot: Use at 1:1,000 ~ 2,000.

Optimal working concentrations should be determined experimentally by the end user.

Calculated MW

70 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Supplied in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human NRG1 isoform HRG-beta3 (20-241aa) purified from E. coli

Purification

By protein-G affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Neuregulin 1 , Aria , Ggf , Ggf2 , Hgl , Hrg , Hrg1 , Hrga , Mst131 , Mstp131 , Ndf , Nrg1-It2 , Smdf , Nrg1

Cellular Localization

Does not seem to be active. May be nuclear. Has a signal peptide. May possess an internal uncleaved signal sequence.

Background

Neuregulin1 (NRG1) is one of four proteins in the neuregulin family that act on the Epidermal growth factor receptor (EGFR) family of receptors. NRG1 was originally identified as a 44 kDa glycoprotein that interacts with the ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. In many brain areas, NRG1 is expressed at synaptic regions and its processing can be regulated by neuronal activity. This variant (HRG-beta3) of NRG1, along with HRG-alpha, beta1 and beta2 variants, was identified in various normal tissues and cancer cell lines.

Database

Research Area

DATA IMAGES

Anti-Neuregulin-1 antibody [k1G13] used in Western Blot (WB). GTX50038

GTX50038 WB Image

Cell lysates of 293T (20ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human NRG1 (1:1,000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf