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Neuregulin-1 antibody

Cat. No. GTX82945

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC, Neutralizing/Inhibition

Reactivity

 Human, Mouse
Package
500 μl ($449)
See all Neuregulin-1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC Assay dependent
Neutralizing/Inhibition Assay dependent
Not tested in other applications.

Calculated MW

70 kDa. ( Note )

Positive Control

HRGbeta1 recombinant protein, LS174T cells

Product Note

Reacts weakly with alpha-HRG and strongly with beta-HRG. Does not inhibit the binding of HRG to ErbB receptors but it efficiently blocks the HRG-induced proliferation and differentiation of cultured human mammary cells.

PROPERTIES

Form

Liquid

Buffer

buffer

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

A highly antigenic synthetic peptide from the EGF-like domain of human heregulin

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

neuregulin 1 , ARIA , GGF , GGF2 , HGL , HRG , HRG1 , HRGA , MST131 , MSTP131 , NDF , NRG1-IT2 , SMDF

Background

The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]

Database

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 449