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Neuregulin-1 antibody

Anti-Neuregulin-1 antibody used in Western Blot (WB). GTX82945

Cat No. GTX82945

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, Blocking, IHC
Reactivity Human, Mouse
Package
500 μl ($339)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
Blocking Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

70 kDa. ( Note )

Positive Control

HRGbeta1 recombinant protein, LS174T cells

Specificity/Sensitivity

Reacts weakly with alpha-HRG and strongly with beta-HRG. Does not inhibit the binding of HRG to ErbB receptors but it efficiently blocks the HRG-induced proliferation and differentiation of cultured human mammary cells.
PROPERTIES

Form

Liquid

Buffer

Buffer without any additives.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A highly antigenic synthetic peptide from the EGF-like domain of human heregulin

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Neuregulin 1,Aria,Ggf,Ggf2,Hgl,Hrg,Hrg1,Hrga,Mst131,Mstp131,Ndf,Nrg1-It2,Smdf,Nrg1

Cellular Localization

Cell membrane,Membrane,Nucleus,Secreted

Background

The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]

Research Area

DATA IMAGES
Anti-Neuregulin-1 antibody used in Western Blot (WB). GTX82945

GTX82945 WB Image

Western blot analysis of Heregulin using GTX82945

REFERENCE
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REVIEW
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Package List Price ($)
$ 339