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Neurexin 1 antibody

KO/KD Orthogonal
Anti-Neurexin 1 antibody used in Live cell imaging (LCI). GTX54845
Anti-Neurexin 1 antibody used in Western Blot (WB). GTX54845

Cat. No. GTX54845

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-Fr, LCI

Reactivity

 Human, Mouse, Rat
Package
50 μl ($639)
See all Neurexin 1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-Fr Assay dependent
LCI Assay dependent
Not tested in other applications.

Calculated MW

168 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.8 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

Peptide (C)KPRHQKDAKHPQMIK, corresponding to amino acid residues 546-560 (Extracellular, N-terminus) of rat Neurexin 1α (Accession  : Q63372).

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

neurexin 1 , Nrxn1b

Cellular Localization

Cell membrane; Single-pass type I membrane protein

Background

This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. [provided by RefSeq, Nov 2016]

Database

Research Area

DATA IMAGES

Anti-Neurexin 1 antibody used in Live cell imaging (LCI). GTX54845

GTX54845 LCI Image

Live cell imaging analysis of intact living PC12 cells using GTX54845 Neurexin 1 antibody.
Panel A : Primary antibody
Panel B : Live view of the cell
Dilution : 1:50

Anti-Neurexin 1 antibody used in Western Blot (WB). GTX54845

GTX54845 WB Image

WB analysis of rat brain (lanes 1 and 3) and mouse brain (lanes 2 and 4) lysates using GTX54845 Neurexin 1 antibody preincubated with or without immunogen peptide.
Dilution : 1:400

REFERENCE

Application Reference

Wu D et al. J Neurodev Disord 2023; 15 (1) : 6 NRXN1 depletion in the medial prefrontal cortex induces anxiety-like behaviors and abnormal social phenotypes along with impaired neurite outgrowth in rat.
Application : ICC/IF, IHC-Fr
Reactivity : Rat
Submit a Reference

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 639