GeneTex
United States (US)

Neuropeptide Y antibody [8]

GTX60971_20170208_ICCIF_18121411_480.jpg
GTX60971_20170208_IHC-P_18121411_396.jpg
GTX60971_20170208_ICCIF_1_18121411_393.jpg
GTX60971_20170208_IHC-P_2_18121411_190.jpg
GTX60971_20170208_IHC-P_1_18121411_411.jpg

Cat No. GTX60971

Host Mouse
Clonality Monoclonal
Clone Name 8
Isotype IgG1
Application ICC/IF, IHC-P, ELISA
Reactivity Human, Mouse, Rat
APPLICATION

Calculated MW

11 kDa. ( Note )

Specificity/Sensitivity

This antibody binds full length human/rat Neuropeptide Y (NPY). Cross-reactivity with NPY (1-24) , NPY (18-36), PYY or PP was <0.2%.
PROPERTIES

Form

Liquid

Buffer

0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Antigen Species

Human

Immunogen

Synthetic human/rat neuropeptide Y

Purification

Protein-A purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

NPY Antibody , PYY4 Antibody , neuropeptide Y Antibody

Background

This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

Database

Research Area

DATA IMAGES
GTX60971_20170208_ICCIF_18121411_480.jpg

GTX60971 ICC/IF Image

GTX60971 tested on tissue from human cerebral cortex, applying ultra thin sections using a technique called array tomography. (antibody: green, DAPI-stained nuclei: blue). The antibody labels NPY-positive processes in the neutrophil. Courtesy of Dr. Nancy O'Rourke, Stanford University.

GTX60971_20170208_IHC-P_18121411_396.jpg

GTX60971 IHC-P Image

Paraffin embedded mouse brain tissue (fibres in the hilus of the hippocampus) from a mouse suffering an epiletic attack just before perfusion stained with GTX60971 diluted 1/1000

GTX60971_20170208_ICCIF_1_18121411_393.jpg

GTX60971 ICC/IF Image

GTX60971 tested on tissue from human cerebral cortex, applying ultra thin sections using a technique called array tomography. (antibody: green, DAPI-stained nuclei: blue). The antibody labels NPY-positive processes in the neutrophil. Courtesy of Dr. Nancy O'Rourke, Stanford University.

GTX60971_20170208_IHC-P_2_18121411_190.jpg

GTX60971 IHC-P Image

Paraffin embedded mouse brain tissue (interneurons in the cortex) stained with GTX60971 diluted 1/1000

GTX60971_20170208_IHC-P_1_18121411_411.jpg

GTX60971 IHC-P Image

Enlarged section of a paraffin embedded mouse brain tissue (fibres in the hilus of the hippocampus) from a mouse suffering an epileptic attack just before perfusion stained with GTX60971 diluted 1/1000

Package List Price ($)
$ 329