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Neurturin antibody

Anti-Neurturin antibody used in IHC (Paraffin sections) (IHC-P). GTX85089
Anti-Neurturin antibody used in IHC (Paraffin sections) (IHC-P). GTX85089
Anti-Neurturin antibody used in IHC (Paraffin sections) (IHC-P). GTX85089
Anti-Neurturin antibody used in Western Blot (WB). GTX85089

Cat. No. GTX85089

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse
Package
100 μg ($409)
See all Neurturin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P 5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

22 kDa. ( Note )

Positive Control

Human Brain Tissue Slide(GTX22203) , Jurkat Cell Lysate(GTX27899) , Human Brain Tissue Lysate(GTX27918)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Neurturin antibody was raised against a 16 amino acid peptide near the carboxy terminus of human Neurturin.The immunogen is located within the last 50 amino acids of Neurturin.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

neurturin , NTN

Cellular Localization

Secreted

Background

Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRalpha. The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently (3-8) and termed GDNFRb, Ret ligand 2 (RETL2) or TGF-Β-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRalpha-2 recently. NTN binds to and forms a complex with GFRalpha-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.

Database

Research Area

DATA IMAGES

Anti-Neurturin antibody used in IHC (Paraffin sections) (IHC-P). GTX85089

GTX85089 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX85089 Neurturin antibody.
Working concentration : 5 μg/ml

Anti-Neurturin antibody used in IHC (Paraffin sections) (IHC-P). GTX85089

GTX85089 IHC-P Image

IHC-P analysis of human brain tissue using GTX85089 Neurturin antibody.
Working concentration : 5 μg/ml

Anti-Neurturin antibody used in IHC (Paraffin sections) (IHC-P). GTX85089

GTX85089 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX85089 Neurturin antibody.
Working concentration : 20 μg/ml
Green : Primary antibody
Blue : DAPI
Red : Actin

Anti-Neurturin antibody used in Western Blot (WB). GTX85089

GTX85089 WB Image

WB analysis of HeLa cell lyaste containing 10 or 2.5 ng of full length recombinant NTN protein using GTX85089 Neurturin antibody.
Working concentration : 1:500

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 409