*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
293T , HeLa , HepG2
Mouse, Rat, Bovine, Dog, Rhesus Monkey(>80% identity)
1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.)
Recombinant protein encompassing a sequence within the center region of human Nicastrin. The exact sequence is proprietary.
Purified by antigen-affinity chromatography.
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
APH2 antibody, KIAA0253 antibody, NCSTN antibody, nicastrin antibody, anterior pharynx-defective 2 antibody, ATAG1874 antibody
Membrane; Single-pass type I membrane protein (Potential) , Melanosome
This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq]
GTX115930 ICC/IF Image
Immunofluorescence analysis of methanol-fixed HeLa, using Nicastrin(GTX115930) antibody at 1:500 dilution.
GTX115930 WB Image
Sample (30 ug of whole cell lysate)
5% SDS PAGE
GTX115930 diluted at 1:500