GeneTex

  • Country / Location Selection

United States (US)

Nicastrin antibody

Anti-Nicastrin antibody used in Western Blot (WB). GTX23444
Anti-Nicastrin antibody used in Western Blot (WB). GTX23444

Cat. No. GTX23444

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all Nicastrin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 2 μg/ml
Not tested in other applications.

Calculated MW

78 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic Peptide: C(688) I N A K A D V L F I A P R E P G A V S Y(708)

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

nicastrin , ATAG1874

Cellular Localization

Membrane

Background

This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]

Database

Research Area

DATA IMAGES

Anti-Nicastrin antibody used in Western Blot (WB). GTX23444

GTX23444 WB Image

WB analysis of membrane extracts (30 μglysate) of T98G (Lane 1), and RSC96 (Lane 2) using GTX23444 Nicastrin antibody.
Dilution : 2 μg/ml

Anti-Nicastrin antibody used in Western Blot (WB). GTX23444

GTX23444 WB Image

WB analysis of mouse primary cultured neuronal cells using GTX23444 Nicastrin antibody.

REFERENCE

There are currently no references for Nicastrin antibody (GTX23444). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for Nicastrin antibody (GTX23444). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399