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Nicastrin antibody

Anti-Nicastrin antibody used in IHC (Paraffin sections) (IHC-P). GTX31752
Anti-Nicastrin antibody used in IHC (Paraffin sections) (IHC-P). GTX31752
Anti-Nicastrin antibody used in Western Blot (WB). GTX31752
Anti-Nicastrin antibody used in IHC (Paraffin sections) (IHC-P). GTX31752

Cat No. GTX31752

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P, ELISA

Reactivity

Human, Mouse, Rat
Package
100 μg ($339)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5 - 1 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

78 kDa. ( Note )

Positive Control

Human Brain Tissue Slide(GTX22203) , Human Brain Tissue Lysate(GTX27918)

PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Nicastrin antibody was raised against a 18 amino acid synthetic peptide from near the center of human Nicastrin.The immunogen is located within amino acids 370 - 420 of Nicastrin.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

nicastrin , ATAG1874

Cellular Localization

Membrane

Background

This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Nicastrin antibody used in IHC (Paraffin sections) (IHC-P). GTX31752

GTX31752 IHC-P Image

IHC-P analysis of human brain tissue using GTX31752 Nicastrin antibody.
Working concentration : 20 μg/ml

Anti-Nicastrin antibody used in IHC (Paraffin sections) (IHC-P). GTX31752

GTX31752 IHC-P Image

IHC-P analysis of human brain tissue using GTX31752 Nicastrin antibody.
Working concentration : 2.5 μg/ml

Anti-Nicastrin antibody used in Western Blot (WB). GTX31752

GTX31752 WB Image

WB analysis of human brain tissue lysate using GTX31752 Nicastrin antibody.
Working concentration : (A) 0.5 and (B) 1 μg/ml

Anti-Nicastrin antibody used in IHC (Paraffin sections) (IHC-P). GTX31752

GTX31752 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX31752 Nicastrin antibody.
Working concentration : 20 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 339