GeneTex
United States (US)

Nkx2.2 antibody [NX2/294]

GTX34908_20170712_IHC-P_2_18121410_709.jpg
GTX34908_20170712_IHC-P_1_18121410_305.jpg
GTX34908_20170712_IHC-P_18121410_779.jpg

Cat No. GTX34908

Host Mouse
Clonality Monoclonal
Clone Name NX2/294
Isotype IgG2b
Application IHC-P
Reactivity Human, Mouse, Rat, Chicken
APPLICATION

Application Note

IHC-P:0.5-1ug/ml for 30 minutes at RT.

Calculated MW

30 kDa. ( Note )

Specificity/Sensitivity

Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Human full-length recombinant NKX2.2 protein

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Nk2 Homeobox 2,Nkx2.2,Nkx2B,Nkx2-2

Background

The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
GTX34908_20170712_IHC-P_2_18121410_709.jpg

GTX34908 IHC-P Image

Formalin-fixed, paraffin-embedded Rat Pancreas stained with NKX2.2 Monoclonal Antibody (NX2/294).

GTX34908_20170712_IHC-P_1_18121410_305.jpg

GTX34908 IHC-P Image

Formalin-fixed, paraffin-embedded human Pancreas stained with NKX2.2 Monoclonal Antibody (NX2/294).

GTX34908_20170712_IHC-P_18121410_779.jpg

GTX34908 IHC-P Image

Formalin-fixed, paraffin-embedded human Ewing's Sarcoma stained with NKX2.2 Monoclonal Antibody (NX2/294).

Package List Price ($)
$ 329