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Nociceptin antibody

Cat No. GTX10276

Host Guinea pig
Clonality Polyclonal
Isotype IgG
Application IHC-Fr
Reactivity Rat, Primate
Package
50 μl ($319)
APPLICATION

Application Note

IHC-Fr: Use at a dilution of 1/500. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

20 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Preservative: 0.05% Sodium Azide; Constituents: Whole Serum

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Rat

Immunogen

Synthetic peptide: FGGFTGARKSARKLANQ, corresponding to amino acids 122-138 of Rat Orphanin FQ.

Purification

Whole antiserum

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Prepronociceptin , N23K , Npnc1 , Pnoc

Cellular Localization

Secreted

Background

Orphanin FQ (nociceptin, OFQ), a heptadecapeptide peptide, has been designated as an endogenous ligand for the ORL1 receptor. The amino acid sequence of OFQ hashomology with other opioid peptides, especially the prodynorphin fragment dynorphin A, suggesting a close evolutionary relationship between the precursors. A diffuse distribution throughout the brain is seen with binding studies and in situ hybridization suggesting an extensive role for OFQ in a multitude of CNS functions. Immunocytochemical localizations in rat spinal cord have demonstrated OFQ abundance in superficial dorsal horn, lateral spinal nucleus and the region dorsal to the central canal. OFQ immunoreactivity was not affected by dorsal rhizotomy, indicating that in spinal cord the peptide is produced by central rather than primary afferent neurons. The localization is supported by its function in processing of nociceptive signals.

Database

Research Area

REFERENCE
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REVIEW
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Package List Price ($)
$ 319