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Nuclear Matrix Protein p84 antibody [5E10] (HRP)

Orthogonal
Anti-Nuclear Matrix Protein p84 antibody [5E10] (HRP) used in Western Blot (WB). GTX70220-01
Anti-Nuclear Matrix Protein p84 antibody [5E10] (HRP) used in Western Blot (WB). GTX70220-01

Cat. No. GTX70220-01

Reference 157

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 5E10

Isotype

 IgG2b

Application

 WB

Reactivity

 Human, Mouse
Package
100 μl ($399)
See all Nuclear Matrix Protein p84 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
Not tested in other applications.

Calculated MW

76 kDa. ( Note )

Positive Control

Jurkat , Raji , NCI-H929 , HeLa , HeLa nuclear

PROPERTIES

Form

Liquid

Buffer

0.05M Tris, 0.15M NaCl, 1%BSA

Preservative

0.005% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.3 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Amino acids 15-374 of human p84 expressed in E. coli.

Purification

Affinity purified by Protein G.

Conjugation

Horseradish peroxidase(HRP)

RRID

AB_2888615

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

THO complex 1 , HPR1 , P84 , P84N5

Cellular Localization

nucleoplasm , Cytoplasm

Background

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010]

Database

Research Area

DATA IMAGES

Anti-Nuclear Matrix Protein p84 antibody [5E10] (HRP) used in Western Blot (WB). GTX70220-01

GTX70220-01 WB Image

Orthogonal

p84 antibody [5E10] (HRP) detects p84 protein by western blot analysis.
A. 30 μg HeLa whole cell lysate/extract
B. 30 μg HeLa nuclear lysate/extract
7.5 % SDS-PAGE
p84 antibody [5E10] (HRP) (GTX670220-01) dilution: 1:1000

Anti-Nuclear Matrix Protein p84 antibody [5E10] (HRP) used in Western Blot (WB). GTX70220-01

GTX70220-01 WB Image

p84 antibody [5E10] (HRP) detects p84 protein by western blot analysis.
A. 30 μg Jurkat whole cell lysate/extract
B. 30 μg Raji whole cell lysate/extract
C. 30 μg NCI-H929 whole cell lysate/extract
7.5 % SDS-PAGE
p84 antibody [5E10] (HRP) (GTX70220-01) dilution: 1:1000

REFERENCE

Application Reference

Escalante-Covarrubias Q et al. Nat Commun 2023; 14 (1) : 1685 Time-of-day defines NAD(+) efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice.
Application : WB
Reactivity : Mouse

Clone Reference

Arimoto KI et al. Nat Commun 2023; 14 (1):251 Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis.
Daniel Whisenant et al. Nat Commun 2022; 13 (1):3068 Transient expression of an adenine base editor corrects the Hutchinson-Gilford progeria syndrome mutation and improves the skin phenotype in mice.
Shujun Wang et al. Oxid Med Cell Longev 2022; 2022:2812493 Activation of Transcription Factor EB Alleviates Tubular Epithelial Cell Injury via Restoring Lysosomal Homeostasis in Diabetic Nephropathy.
Hsiao YW et al. Clin Transl Med 2022; 12 (1):e724 Disruption of the pentraxin 3/CD44 interaction as an efficient therapy for triple-negative breast cancers.
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REVIEW

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Application Reference
Escalante-Covarrubias Q et al. Nat Commun 2023; 14 (1):1685 Time-of-day defines NAD(+) efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice.
Application : WB
Reactivity : Mouse
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Taura M et al. Proc Natl Acad Sci U S A 2019; 116 (6):2282-2289 Apobec3A maintains HIV-1 latency through recruitment of epigenetic silencing machinery to the long terminal repeat.
Application : WB
Reactivity : Human
Clone Reference
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Shujun Wang et al. Oxid Med Cell Longev 2022; 2022:2812493 Activation of Transcription Factor EB Alleviates Tubular Epithelial Cell Injury via Restoring Lysosomal Homeostasis in Diabetic Nephropathy.
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Lee SK et al. Cardiovasc Res 2011; 91 (3):502-9 Apurinic/apyrimidinic endonuclease 1 inhibits protein kinase C-mediated p66shc phosphorylation and vasoconstriction.
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Mancini A et al. BMC Biol 2010; 8:1 THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo.
Wang X et al. Mol Cell Biol 2009; 29 (10):2794-803 Thoc1 deficiency compromises gene expression necessary for normal testis development in the mouse.
El Bounkari O et al. FEBS Lett 2009; 583 (1):43325 Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP).
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Byun HS et al. Rheumatology (Oxford) 2008; 47 (3):301-8 Caspase-8 has an essential role in resveratrol-induced apoptosis of rheumatoid fibroblast-like synoviocytes.
Ji Y et al. Mol Cancer Res 2007; 5 (10):1041-51 Mouse embryo fibroblasts lacking the tumor suppressor menin show altered expression of extracellular matrix protein genes.
Nini L et al. BMC Biochem 2007; 8:18 R7-binding protein targets the G protein beta 5/R7-regulator of G protein signaling complex to lipid rafts in neuronal cells and brain.
Mancini A et al. Oncogene 2007; 26 (7):1020-7 FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha.
Li Y et al. Cancer Res 2007; 67 (14):6657-64 Cancer cells and normal cells differ in their requirements for Thoc1.
Birle DC et al. Cancer Res 2007; 67 (4):1735-43 Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors.
Wang X et al. Mol Cell Biol 2006; 26 (11):899410 Thoc1/Hpr1/p84 is essential for early embryonic development in the mouse.
Li Y et al. Mol Cell Biol 2005; 25 (10):4023-33 Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.
Gasparri F et al. FEBS Lett 2004; 574 (43103):43356 The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm.
Sukhodolets KE et al. Mol Cell Biol 2003; 23 (2):493-509 The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene.
Agarwal SK et al. Proc Natl Acad Sci U S A 2003; 100 (19):10770-5 Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter.
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Thimerosal.pdf
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