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Nuclear Matrix Protein p84 antibody [5E10]

KO/KD Orthogonal
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in IHC (Paraffin sections) (IHC-P). GTX70220
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX70220
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Immunoprecipitation (IP). GTX70220
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in IHC (Paraffin sections) (IHC-P). GTX70220
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220

Cat. No. GTX70220

Reference 148
18

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 5E10

Isotype

 IgG2b

Application

 WB, ICC/IF, IHC-P, IP, ChIP assay, IHC

Reactivity

 Human, Mouse, Rat, Hamster, Monkey
Package
100 μl ($399)
See all Nuclear Matrix Protein p84 products
PRODUCT

Summary

Nuclear Matrix Protein p84 antibody detects THO complex subunit 1, which is an 84 kDa nuclear matrix protein often referred to as just “p84”. p84 is involved in mRNA transcription and is considered to be a nuclear marker. p84 antibody is an effective reagent used to verify the purity of nuclear extracts in cellular fractionation assays.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.3 - 2 μg/ml
ICC/IF 0.5 - 2 μg/ml
IHC-P Assay dependent
IP 1:100-1:500
ChIP assay Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

76 kDa. ( Note )

Positive Control

293T , A431 , HeLa , HepG2 , A375 , HeLa nucleus , NIH-3T3 , mouse brain , PC-12 , mouse Cerebellum

Product Note

Knockdown/Knockout validation was supported by references (PMID:25296641)

PROPERTIES

Form

Liquid

Buffer

1XPBS pH7, 20% Glycerol

Preservative

No Preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Amino acids 15-374 of human p84 expressed in E. coli.

Purification

Protein G purified

Conjugation

Unconjugated

RRID

AB_372637

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

THO complex 1 , HPR1 , P84 , P84N5

Cellular Localization

nucleoplasm , Cytoplasm

Background

HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010]

Database

Research Area

DATA IMAGES

Anti-Nuclear Matrix Protein p84 antibody [5E10] used in IHC (Paraffin sections) (IHC-P). GTX70220

GTX70220 IHC-P Image

Nuclear Matrix Protein p84 antibody [5E10] detects Nuclear Matrix Protein p84 protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded human breast carcinoma.
Nuclear Matrix Protein p84 stained by Nuclear Matrix Protein p84 antibody [5E10] (GTX70220) diluted at 1:200.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220

GTX70220 WB Image

Detection of human p84/N5 in nuclear fraction by anti-p84/N5 5E10 monoclonal antibody (GTX70220) in western blot experiment. Lane 1: total lysate, Lane 2: cytoplasmic fraction, Lane 3: membrane fraction, Lane 4: nuclear fraction.

Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX70220

GTX70220 ICC/IF Image

Nuclear Matrix Protein p84 antibody [5E10] detects Nuclear Matrix Protein p84 protein at nucleus by immunofluorescent analysis.
Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: Nuclear Matrix Protein p84 stained by Nuclear Matrix Protein p84 antibody [5E10] (GTX70220) diluted at 1:500.
Red: phalloidin, a cytoskeleton marker, diluted at 1:100.

Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Immunoprecipitation (IP). GTX70220

GTX70220 IP Image

p84 antibody [5E10] immunoprecipitates p84 protein in IP experiments. IP Sample: HepG2 whole cell lysate/extract A : 30 μg whole cell lysate/extract of p84 protein expressing HepG2 cells B : Control with 3 μg of pre-immune mouse IgG C : Immunoprecipitation of p84 by 3 μg of p84 antibody [5E10] (GTX70220) 7.5% SDS-PAGE The immunoprecipitated p84 protein was detected by p84 antibody [5E10] (GTX70220) diluted at 1 : 1000. EasyBlot anti-rabbit IgG (HRP) (GTX221667-01) was used as a secondary reagent.

Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220

GTX70220 WB Image

Various whole cell extracts (30 μg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with Nuclear Matrix Protein p84 antibody [5E10] (GTX70220) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-Nuclear Matrix Protein p84 antibody [5E10] used in IHC (Paraffin sections) (IHC-P). GTX70220

GTX70220 IHC-P Image

Nuclear Matrix Protein p84 antibody [5E10] detects Nuclear Matrix Protein p84 protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded human lung cancer.
Nuclear Matrix Protein p84 stained by Nuclear Matrix Protein p84 antibody [5E10] (GTX70220) diluted at 1:100.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220

GTX70220 WB Image

Sample (30 μg of whole cell lysate)
A: HeLa
B: HeLa nucleus
7.5% SDS PAGE
GTX70220 diluted at 1:1000
The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220

GTX70220 WB Image

Sample (50 μg of whole cell lysate)
A: mouse Cerebellum
7.5% SDS PAGE
GTX70220 diluted at 1:1000
The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220

GTX70220 WB Image

Sample (whole cell lysate)
A: 293T 20ug
B: 293T 10ug
C: 293T 5ug
7.5% SDS PAGE
GTX70220 diluted at 1:1000
The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

REFERENCE

Application Reference

Yu-Wei Hsiao et al. Clin Transl Med. 2022; 12 (1) : e724 Disruption of the pentraxin 3/CD44 interaction as an efficient therapy for triple-negative breast cancers
Application : WB
Reactivity : Human
Jyun-Yi Du et al. J Immunol Res . 2022; 2022:8953235 Pentraxin 3 Facilitates Shrimp-Allergic Responses in IgE-Activated Mast Cells
Application : WB
Reactivity : Mouse, Rat
Daniel Whisenant et al. Nat Commun 2022; 13 (1) : 3068 Transient expression of an adenine base editor corrects the Hutchinson-Gilford progeria syndrome mutation and improves the skin phenotype in mice.
Application : WB
Reactivity : Human
Shujun Wang et al. Oxid Med Cell Longev 2022; 2022 : 2812493 Activation of Transcription Factor EB Alleviates Tubular Epithelial Cell Injury via Restoring Lysosomal Homeostasis in Diabetic Nephropathy.
Application : WB
Reactivity : Human
Josephine Mun Yee Ko et al. Cancers (Basel) 2021; 13 (18) RAD50 Loss of Function Variants in the Zinc Hook Domain Associated with Higher Risk of Familial Esophageal Squamous Cell Carcinoma.
Application : WB
Reactivity : Human
Show More +
Submit a Reference

REVIEW

Nuclear Matrix Protein p84 antibody [5E10] Cat. No. GTX70220

Rating
( Average 5 based on 18 users reviews)
Application
Western Blot(WB)
( Average 5 based on 18 users reviews)
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 03-Oct-2022
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the 2019 in Elife. PMID: 31663849
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 03-Oct-2022
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the 2019 in Elife. PMID: 31663849
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 22-Feb-2022
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the Nat Commun in 2020. PMID: 33257668
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Nat Commun in 2016.PMID: 27046438
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Nat Commun in 2016.PMID: 27046438
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Mk
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2013.PMID: 23805200
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal EMBO Mol Med in 2013. PMID: 23341130
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal J Biomed Sci in 2014. PMID: 25030234
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Sci Rep in 2017. PMID: 28157211
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Biomed Res Int in 2015. PMID: 25834829
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Sci Rep in 2017. PMID: 28157211
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal EMBO Mol Med in 2013. PMID: 23341130
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2017. PMID: 29045486
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2017. PMID: 29045486
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Biomed Res Int in 2015. PMID: 25722974
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS Pathog in 2015. PMID: 25927232
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Rat
Figure Note : The data was peer reviewed and published in the journal BMC Biochem in 2007. PMID: 17880698
Anti-Nuclear Matrix Protein p84 antibody [5E10] used in Western Blot (WB). GTX70220
Date : Anonymous submitted on 06-Feb-2012
Score :
Application Tested : WB
Sample Species : Hu
Sample : 293T cells
Amount used : 30μg
Blocking : TBST with 5% milk, 25°C, 1Hr
Primary Antibody : 1:1000, 4°C, 12Hr
Show More +
Submit a Review
Application Reference
Yu-Wei Hsiao et al. Clin Transl Med. 2022; 12 (1):e724 Disruption of the pentraxin 3/CD44 interaction as an efficient therapy for triple-negative breast cancers
Application : WB
Reactivity : Human
Jyun-Yi Du et al. J Immunol Res . 2022; 2022:8953235 Pentraxin 3 Facilitates Shrimp-Allergic Responses in IgE-Activated Mast Cells
Application : WB
Reactivity : Mouse, Rat
Daniel Whisenant et al. Nat Commun 2022; 13 (1):3068 Transient expression of an adenine base editor corrects the Hutchinson-Gilford progeria syndrome mutation and improves the skin phenotype in mice.
Application : WB
Reactivity : Human
Shujun Wang et al. Oxid Med Cell Longev 2022; 2022:2812493 Activation of Transcription Factor EB Alleviates Tubular Epithelial Cell Injury via Restoring Lysosomal Homeostasis in Diabetic Nephropathy.
Application : WB
Reactivity : Human
Xue Chen et al. Elife 2021; 10 A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells.
Application : WB
Reactivity : Mouse
Jessie Kulsuptrakul et al. Cell Rep 2021; 34 (11):108859 A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection.
Application : WB
Reactivity : Human
Sheyne Sta Ana Choi et al. Oncol Lett 2021; 22 (1):513 Differentiation-related zinc finger protein 750 suppresses cell growth in esophageal squamous cell carcinoma.
Application : WB
Reactivity : Human
Kevin B Koronowski et al. Cell Rep 2021; 36 (5):109487 Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation.
Application : WB
Reactivity : Human, Mouse
Josephine Mun Yee Ko et al. Cancers (Basel) 2021; 13 (18) RAD50 Loss of Function Variants in the Zinc Hook Domain Associated with Higher Risk of Familial Esophageal Squamous Cell Carcinoma.
Application : WB
Reactivity : Human
Willmer T et al. Am J Cancer Res 2021; 11 (11):5680-5700 Targeting the oncogenic TBX3:nucleolin complex to treat multiple sarcoma subtypes.
Application : WB
Greco CM et al. Sci Adv 2021; 7 (39):eabi7828 Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms.
Application : WB
Reactivity : Mouse
Santiago Gonz?lez DA et al. Redox Biol 2021; 46:102118 Ceruloplasmin deletion in myelinating glial cells induces myelin disruption and oxidative stress in the central and peripheral nervous systems.
Application : WB
Reactivity : Mouse
Sriramajayam K et al. Redox Biol 2021; 43:101970 Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells.
Application : WB
Wang SM et al. Cell Death Discov 2021; 7 (1):8 CCAAT/Enhancer-binding protein delta mediates glioma stem-like cell enrichment and ATP-binding cassette transporter ABCA1 activation for temozolomide resistance in glioblastoma.
Application : WB
Reactivity : Human
Yu VZ et al. Transl Oncol 2021; 14 (1):100982 Gain-of-function hot spot mutant p53R248Q regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma.
Application : WB
Reactivity : Human
Carolina Magdalen Greco et al. Sci Adv 2020; 6 (51) S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling.
Application : WB
Reactivity : Human
Amika Singla et al. Dis Model Mech 2020; Regulation of murine copper homeostasis by members of the COMMD protein family.
Application : WB
Reactivity : Mouse
Tolchin D et al. Am J Hum Genet 2020; 106 (6):830-845 De Novo SOX6 Variants Cause a Neurodevelopmental Syndrome Associated with ADHD, Craniosynostosis, and Osteochondromas.
Application : WB
Reactivity : Human
Zhou X et al. Nat Commun 2020; 11 (1):6088 Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus.
Application : WB
Reactivity : Mouse
Lei LC et al. Cancers (Basel) 2020; 12 (9) FANCD2 Confers a Malignant Phenotype in Esophageal Squamous Cell Carcinoma by Regulating Cell Cycle Progression.
Application : WB
Reactivity : Human
Shrestha R et al. Am J Cancer Res 2020; 10 (8):2495-2509 Bis-indole derived nuclear receptor 4A1 (NR4A1) antagonists inhibit TGFβ-induced invasion of embryonal rhabdomyosarcoma cells.
Application : WB
Reactivity : Human
Nicholas DA et al. Sci Rep 2020; 10 (1):13063 GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes.
Application : WB
Reactivity : Mouse
Wan R et al. J Neurosci 2020; 40 (40):7609-7624 Impaired Postnatal Myelination in a Conditional Knockout Mouse for the Ferritin Heavy Chain in Oligodendroglial Cells.
Application : WB
Reactivity : Mouse
Deng M et al. Cancers (Basel) 2020; 12 (7) Cylindromatosis Lysine 63 Deubiquitinase (CYLD) Regulates NF-kB Signaling Pathway and Modulates Fibroblast and Endothelial Cells Recruitment in Nasopharyngeal Carcinoma.
Application : WB
Reactivity : Human
Sueyasu T et al. Eur Rev Med Pharmacol Sci 2020; 24 (4):2110-2119 Dietary arachidonic acid improves age-related excessive enhancement of the stress response.
Application : WB
Reactivity : Mouse
Treger RS et al. Immunity 2019; 50 (2):334-347.e9 The Lupus Susceptibility Locus Sgp3 Encodes the Suppressor of Endogenous Retrovirus Expression SNERV.
Diep J et al. Nat Microbiol 2019; 4 (12):2523-2537 Enterovirus pathogenesis requires the host methyltransferase SETD3.
Taura M et al. Proc Natl Acad Sci U S A 2019; 116 (6):2282-2289 Apobec3A maintains HIV-1 latency through recruitment of epigenetic silencing machinery to the long terminal repeat.
Sifuentes-Dominguez LF et al. Elife 2019; 8 SCGN deficiency results in colitis susceptibility.
Application : IP
Santiago Gonz獺lez DA et al. J Neurosci 2019; (Epub) Iron metabolism in the peripheral nervous system: the role of DMT1, ferritin and transferrin receptor in Schwann cell maturation and myelination.
Application : WB
Reactivity : Mouse
Meyer LK et al. J Clin Invest 2019; (Epub) Glucocorticoids paradoxically facilitate steroid resistance in T-cell acute lymphoblastic leukemias and thymocytes.
Application : WB
Reactivity : Human
Karoulias SZ et al. Matrix Biol 2019; (Epub) A novel ADAMTS17 variant that causes Weill-Marchesani syndrome 4 alters fibrillin-1 and collagen type I deposition in the extracellular matrix.
Application : WB
Reactivity : Human
Min Chen et al. bioRxiv 2019; (Epub) Integrin α6β4 signaling switches DNA repair from homologous recombination to non-homologous end-joining pathway to sensitize breast cancer cells to cisplatin.
Application : WB
Reactivity : Human
Ngo AM et al. Elife 2019; 8 The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins.
Application : WB
Das A et al. Am J Physiol Cell Physiol 2019; Novel Interaction of Antioxidant-1 with TRAF4: Role in Inflammatory Responses in Endothelial Cells.
Application : WB
Reactivity : Human
Li Y et al. Arch Toxicol 2019; Artemisinin suppresses hepatocellular carcinoma cell growth, migration and invasion by targeting cellular bioenergetics and Hippo-YAP signaling.
Application : WB
Reactivity : Human
Salgia MM et al. Am J Clin Exp Urol 2019; 7 (3):98-109 Different roles of peroxisome proliferator-activated receptor gamma isoforms in prostate cancer.
Application : WB
Reactivity : Human
Chu PL et al. Photodiagnosis Photodyn Ther 2019; (Epub) Vandetanib sensitises head and neck squamous cell carcinoma to photodynamic therapy through modulation of EGFR-dependent DNA repair and the tumour microenvironment.
Application : WB
Reactivity : Human
Hu CM et al. Cell Metab 2019; (Epub) High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells.
Application : WB
Reactivity : Human
Kharade SS et al. Endocrinology 2018; 159 (2):1199-1212 Functional Defects From Endocrine Disease-Associated Mutations in HLXB9 and Its Interacting Partner, NONO.
Kinouchi K et al. Cell Rep 2018; 25 (12):3299-3314.e6 Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle.
Huang MH et al. Pharmacol Res 2018; 139:50-61 Epigenetic targeting DNMT1 of pancreatic ductal adenocarcinoma using interstitial control release biodegrading polymer reduced tumor growth through hedgehog pathway inhibition.
Application : WB
Reactivity : Human
Dipendra Gautam et al. Plos Pathogens 2018; (Epub) SETD2-dependent H3K36me3 plays a critical role in epigenetic regulation of the HPV31 life cycle.
Application : WB
Reactivity : Human
Chen MY et al. Cell Death Differ 2018; (Epub) PP4 deficiency leads to DNA replication stress that impairs immunoglobulin class switch efficiency.
Application : WB
Reactivity : Mouse
Ho SR et al. J Biol Chem 2018; (Epub) RNF144A Sustains EGFR Signaling to Promote EGF-Dependent Cell Proliferation.
Application : WB
Reactivity : Human
Li M et al. Nat Commun 2018; 9 (1):2706 SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts.
Reactivity : Human
Bhat AA et al. Oncogene 2018; (Epub) Exposure of Barrett's and esophageal adenocarcinoma cells to bile acids activates EGFR-STAT3 signaling axis via induction of APE1.
Wang J et al. Viruses 2018; 10 (6) Host Long Noncoding RNA lncRNA-PAAN Regulates the Replication of Influenza A Virus.
Application : WB
Reactivity : Human
Parekh VI et al. Endocr Relat Cancer 2018; 25 (5):L31-L35 frequency and consequence of the recurrent yy1 p.t372r mutation in sporadic *omas.
Application : WB
Reactivity : Human
Ram?rez-Peinado S et al. J Cell Sci 2017; 130 (14):2251-2265 TRAPPC13 modulates autophagy and the response to Golgi stress.
Damiani E et al. Sci Rep 2017; 7:41959 Platelet activating factor-induced expression of p21 is correlated with histone acetylation.
Chen CM et al. Proc Natl Acad Sci U S A 2017; 114 (4):E619-E628 Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice.
Puschnik AS et al. Cell Rep 2017; 21 (11):3032-3039 A Small-Molecule Oligosaccharyltransferase Inhibitor with Pan-flaviviral Activity.
Application : WB
Reactivity : Human
Baumann J et al. Mol Biol Cell 2017; (Epub) Golgi stress-induced transcriptional changes mediated by MAPK signaling and three ETS transcription factors regulate MCL1 splicing.
Application : WB
Reactivity : Human
Nikolos F et al. Mol Cancer Res 2017; (Epub) ERβ Sensitizes NSCLC to Chemotherapy by Regulating DNA Damage Response.
Application : WB
Reactivity : Human
Gendarme M et al. Mol Biol Cell 2017; (Epub) Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1.
Application : WB
Reactivity : Human
Zera K et al. PLoS One 2017; 12 (10):e0186707 Thiamine deficiency activates hypoxia inducible factor-1α to facilitate pro-apoptotic responses in mouse primary astrocytes.
Application : WB
Reactivity : Mouse
Tognini P et al. Cell Metab 2017; 26 (3):523-538.e5 Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet.
Application : WB
Reactivity : Mouse
Santiago Gonzalez DA et al. J Neurosci 2017; (Epub) Conditional deletion of the L-type calcium channel Cav1.2 in NG2 positive cells impairs remyelination in mice.
Application : WB
Reactivity : Mouse
Sato S et al. Cell 2017; 170 (4):664-677.e11 Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging.
Application : WB
Reactivity : Mouse
Ramlee M.K. et al. JQVE 2017; Usando una tecnica fluorescente PCR-capillare elettroforesi su gel al genotipo CRISPR / Cas9 mediata Knockout Mutants in un formato high-throughput.
Wang VY et al. Mol Cell 2017; Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity.
Application : WB
Reactivity : Mouse
Otto-Duessel M et al. World J Biol Chem 2017; 8 (2):138-150 Identification of neuron selective androgen receptor inhibitors.
Application : WB
Reactivity : Human
Ramlee MK et al. J Vis Exp 2017; (122) Using a Fluorescent PCR-capillary Gel Electrophoresis Technique to Genotype CRISPR/Cas9-mediated Knockout Mutants in a High-throughput Format.
Wu M et al. Nat Commun 2017; 8:13700 Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway.
Application : WB
Reactivity : Mouse
Aguilar-Arnal L et al. Proc Natl Acad Sci U S A 2016; (Epub) Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species.
Application : WB
Reactivity : Mouse
Starokadomskyy P et al. Nat Immunol 2016; 17 (5):495-504 dna polymerase-α regulates the activation of type i *s through cytosolic rna:dna synthesis.
Application : WB
Reactivity : Human
Prieto GA et al. J Neurosci 2016; (Epub) Pharmacological rescue of long-term potentiation in Alzheimer diseased synapses.
Application : WB
Reactivity : Mouse
Kang K et al. Biochem Pharmacol 2016; (Epub) IinQ attenuates systemic inflammatory responses via selectively impairing the Myddosome complex formation upon TLR4 ligation.
Application : WB
Reactivity : Mouse
Zheng H et al. Proc Natl Acad Sci U S A 2016; 113 (40):11283-11288 Whole-exome sequencing identifies multiple loss-of-function mutations of NF-κB pathway regulators in nasopharyngeal carcinoma.
Application : WB
Reactivity : Human
Murakami M et al. EMBO Rep 2016; 17 (9):1292-303 Gut microbiota directs PPARγ-driven reprogramming of the liver circadian clock by nutritional challenge.
Application : WB
Reactivity : Mouse
Li N et al. Mol Cell 2016; 63 (3):470-84 ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes.
Application : WB
Reactivity : Human
Meenalakshmi Chinnam et al. Mol Cell Biol. 2016; 36 (11):1621-7 Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice.
Application : WB
Reactivity : Mouse
Marceau C.D. et al. Nature 2016; 535 (7610):159-63 Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens.
Application : WB
Reactivity : Human
Hedrick E et al. Mol Cell Biol 2016; 36 (9):1383-94 NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration.
Application : WB
Reactivity : Human
Saud SM et al. Cancer Prev Res (Phila) 2016; (Epub) Diallyl Disulfide (DADS), a constituent of garlic, inactivates NFκB and prevents colitis-induced colorectal cancer by inhibiting GSK-3β.
Application : WB
Reactivity : Human
Gordillo GM et al. J Biol Chem 2016; 291 (19):10089-103 Multidrug Resistance-associated Protein-1 (MRP-1)-dependent Glutathione Disulfide (GSSG) Efflux as a Critical Survival Factor for Oxidant-enriched Tumorigenic Endothelial Cells.
Application : WB
Reactivity : Mouse
Marina RJ et al. EMBO J 2016; 35 (3):335-55 TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing.
Application : WB
Reactivity : Human, Hamster
Richmond BW et al. Nat Commun 2016; 7:11240 Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.
Application : WB
Reactivity : Mouse
Damiani E et al. J Invest Dermatol 2015; 135 (12):3034-3040 Platelet-Activating Factor Induces Epigenetic Modifications in Human Mast Cells.
Application : WB
Reactivity : Human
Ghosh M et al. Biomed Res Int 2015; 2015:308461 The interplay between cyclic AMP, MAPK, and NF-κB pathways in response to proinflammatory signals in microglia.
Application : WB
Reactivity : Mouse
Albert JS et al. Orphanet J Rare Dis 2015; 10:27 Impaired osteoblast and osteoclast function characterize the osteoporosis of Snyder - Robinson syndrome.
Application : WB
Reactivity : Human
Frank AK et al. PLoS Genet 2015; 11 (7):e1005410 The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres.
Application : WB
Reactivity : Human
Verweij MC et al. PLoS Pathog 2015; 11 (5):e1004901 varicella viruses inhibit *-stimulated jak-stat signaling through multiple mechanisms.
Application : WB
Reactivity : Monkey
Puebla-Osorio N et al. Cell Death Dis 2015; 6:e1745 Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells.
Application : WB
Reactivity : Human
Bowman J et al. MBio 2015; 6 (6):e01777-15 Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation.
Application : WB
Reactivity : Mouse
Corbett L et al. PLoS One 2015; 10 (11):e0142794 Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine Stimulation of Kupffer Cells.
Application : WB
Reactivity : Human
Goedeke L et al. Nat Med 2015; 21 (11):1280-9 MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels.
Application : WB
Reactivity : Human
Wang SM et al. Mol Neurobiol 2015; (Epub) Astrocytic CCAAT/Enhancer-Binding Protein Delta Contributes to Glial Scar Formation and Impairs Functional Recovery After Spinal Cord Injury.
Application : WB
Reactivity : Mouse
Tontonoz P et al. Mol Cell Biol 2015; 35 (7):1125-38 The orphan nuclear receptor Nur77 is a determinant of myofiber size and * in mice.
Lecona E et al. Mol Cell Biol 2015; 35 (7):1157-68 USP7 cooperates with SCML2 to regulate the activity of PRC1.
Desai SS et al. J Biol Chem 2015; 290 (42):25595-608 pro-oncogenic roles of hlxb9 protein in *oma cells through interaction with nono protein and down-regulation of the c-met inhibitor cblb (casitas b-lineage lymphoma b).
Ho SR et al. J Biol Chem 2015; 290 (38):23026-38 Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain.
Application : WB
Reactivity : Human
Biswas A et al. Am J Physiol Cell Physiol 2015; 309 (5):C296-307 Endothelial cell tumor growth is Ape/ref-1 dependent.
Application : WB
Reactivity : Mouse
Lin AE et al. PLoS Pathog 2015; 11 (4):e1004818 Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection.
Application : WB
Reactivity : Human
Zhu J et al. Eur J Med Chem 2015; 96:196-208 Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors.
Reactivity : Human
Li M et al. Nat Commun 2015; 6:6720 RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability.
Application : WB
Reactivity : Human
Aguilar-Arnal L et al. Nat Struct Mol Biol 2015; 22 (4):312-8 NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1.
Application : WB
Reactivity : Human
Ip JC et al. Biomed Res Int 2015; 2015:910715 A versatile orthotopic nude mouse model for study of esophageal squamous cell carcinoma.
Application : WB
Reactivity : Mouse
Patel JP et al. J Clin Immunol 2015; 35 (2):227-33 Nijmegen Breakage Syndrome Detected by Newborn Screening for T Cell Receptor Excision Circles (TRECs).
Application : WB
Reactivity : Human
Singleton RS et al. Proc Natl Acad Sci U S A 2014; 111 (11):778485 OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation.
Application : WB
Reactivity : Human
Lazic M et al. J Hepatol 2014; 61 (1):107-15 Differential regulation of inflammation and apoptosis in Fas-resistant hepatocyte-specific Bid-deficient mice.
Application : WB
Reactivity : Mouse
Ramirez CM et al. J Lipid Res 2014; 55 (6):1066-76 RNA binding protein HuR regulates the expression of ABCA1.
Application : WB
Reactivity : Human
Nikolos F et al. Mol Cancer Res 2014; 12 (6):843-54 ERβ regulates NSCLC phenotypes by controlling oncogenic RAS signaling.
Application : WB
Reactivity : Human
Chen Y et al. Oncotarget 2014; 5 (12):4283-94 Increased Nek1 expression in renal cell carcinoma cells is associated with decreased sensitivity to DNA-damaging treatment.
Application : WB
Reactivity : Human
Chinnam M et al. J Natl Cancer Inst 2014; 106 (11):pii: dju306 The Thoc1 ribonucleoprotein and prostate cancer progression.
Application : WB
Reactivity : Human, Mouse
Chen Y et al. J Biomed Sci 2014; 21 (1):63 Expression of Nek1 during kidney development and cyst formation in multiple nephron segments in the Nek1-deficient kat2J mouse model of polycystic kidney disease.
Application : WB
Reactivity : Mouse
Wang JT et al. Cell Rep 2014; Impaired p32 Regulation Caused by the Lymphoma-Prone RECQ4 Mutation Drives Mitochondrial Dysfunction.
Application : WB
Reactivity : Human
Nakamura K et al. Molecular Genetics & Genomic Medicine 2014; 2 (4):332-40 A-TWinnipeg: Pathogenesis of rare ATM missense mutation c.6200C>A with decreased protein expression and downstream signaling, early-onset dystonia, cancer, and life-threatening radiotoxicity.
Application : WB
Reactivity : Human
Haga IR et al. J Virol 2014; TRAF2 facilitates Vaccinia virus replication by promoting rapid virus entry.
Application : WB
Reactivity : Human
Costa-Guda J et al. Horm Cancer 2013; 4 (5):301-7 Germline and somatic mutations in cyclin-dependent kinase inhibitor genes CDKN1A, CDKN2B, and CDKN2C in sporadic parathyroid adenomas.
Jeoung M et al. PLoS One 2013; 8 (6):e66067 Functional Integration of the Conserved Domains of Shoc2 Scaffold.
Application : WB
Reactivity : Human
Chow AK et al. PLoS One 2013; 8 (11):e78675 the enhanced metastatic potential of hepatocellular carcinoma (hcc) cells with * resistance.
Application : WB
Reactivity : Human
Pitzonka L et al. Mol Cell Biol 2013; 17 (33):3505-14 The THO ribonucleoprotein complex is required for stem cell homeostasis in the adult mouse small intestine.
Application : WB
Reactivity : Mouse
Sweet RL et al. Int J Vitam Nutr Res 2013; 83 (3):188-97 HIF1-α-Mediated Gene Expression Induced by Vitamin B1 Deficiency.
Application : WB
Eckel-Mahan KL et al. Cell 2013; 155 (7):1464-78 Reprogramming of the circadian clock by nutritional challenge.
Application : WB
Reactivity : Mouse
Reiling JH et al. Nat Cell Biol 2013; 15 (12):1473-85 A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens.
Application : WB
Reactivity : Human
Thomas RL et al. Genes Dev 2013; 27 (12):1365-77 Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure.
Zhu J et al. EMBO Mol Med 2013; 5 (3):353-65 A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia.
Application : WB
Reactivity : Human
Sharma M et al. Nanoscale 2013; 5 (9):3747-56 Gold nanoparticles induce transcriptional activity of NF-κB in a B-lymphocyte cell line.
Wei PC et al. Mol Cell 2012; 48 (5):747-59 Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease.
Application : WB
Reactivity : Mouse
Diamant G et al. Cell Rep 2012; 2 (4):722-31 DSIF restricts NF-κB signaling by coordinating elongation with mRNA processing of negative feedback genes.
Application : WB
Reactivity : Human
Nini L et al. Endocrine 2012; 42 (1):214-7 Expression of the Gβ5/R7-RGS protein complex in pituitary and pancreatic islet cells.
Application : WB
Pang TP et al. Mol Cell Endocrinol 2012; 348 (1):189-97 A physiological role for androgen actions in the absence of androgen receptor DNA binding activity.
Kanungo J et al. Mol Cell Biochem 2012; 359 (43102):95-104 Menin induces endodermal differentiation in aggregated P19 stem cells by modulating the retinoic acid receptors.
Application : WB
Reactivity : Human
Ramachandran S et al. RNA 2011; 17 (11):1957-66 An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.
Chen Y et al. Cell Cycle 2011; 10 (4):655-63 Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.
Application : WB
Reactivity : Human
Lee SK et al. Cardiovasc Res 2011; 91 (3):502-9 Apurinic/apyrimidinic endonuclease 1 inhibits protein kinase C-mediated p66shc phosphorylation and vasoconstriction.
Wang Y et al. Cancer Res 2011; 71 (2):371-82 The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization.
Application : WB
Mancini A et al. BMC Biol 2010; 8:1 THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo.
Application : WB
Reactivity : Mouse
Wang X et al. Mol Cell Biol 2009; 29 (10):2794-803 Thoc1 deficiency compromises gene expression necessary for normal testis development in the mouse.
Application : ChIP assay
Reactivity : Mouse
El Bounkari O et al. FEBS Lett 2009; 583 (1):43325 Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP).
Application : WB
Reactivity : Human
Bhandari R et al. Proc Natl Acad Sci U S A 2008; 105 (7):2349-53 gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of * secretion, growth, and spermiogenesis.
Application : WB
Reactivity : Mouse
Yang J et al. Ann Clin Lab Sci 2008; 38 (2):105-12 Relationships of hHpr1/p84/Thoc1 expression to clinicopathologic characteristics and prognosis in non-small cell lung cancer.
Application : IHC
Reactivity : Human
Byun HS et al. Rheumatology (Oxford) 2008; 47 (3):301-8 Caspase-8 has an essential role in resveratrol-induced apoptosis of rheumatoid fibroblast-like synoviocytes.
Application : WB
Reactivity : Human
Ji Y et al. Mol Cancer Res 2007; 5 (10):1041-51 Mouse embryo fibroblasts lacking the tumor suppressor menin show altered expression of extracellular matrix protein genes.
Application : WB
Reactivity : Mouse
Nini L et al. BMC Biochem 2007; 8:18 R7-binding protein targets the G protein beta 5/R7-regulator of G protein signaling complex to lipid rafts in neuronal cells and brain.
Application : WB
Reactivity : Rat
Mancini A et al. Oncogene 2007; 26 (7):1020-7 FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha.
Li Y et al. Cancer Res 2007; 67 (14):6657-64 Cancer cells and normal cells differ in their requirements for Thoc1.
Application : WB
Reactivity : Human
Birle DC et al. Cancer Res 2007; 67 (4):1735-43 Suppression of the hypoxia-inducible factor-1 response in cervical carcinoma xenografts by proteasome inhibitors.
Application : WB
Reactivity : Human
Wang X et al. Mol Cell Biol 2006; 26 (11):899410 Thoc1/Hpr1/p84 is essential for early embryonic development in the mouse.
Application : ICC/IF
Reactivity : Mouse
Li Y et al. Mol Cell Biol 2005; 25 (10):4023-33 Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.
Application : ICC/IF
Reactivity : Human
Gasparri F et al. FEBS Lett 2004; 574 (43103):43356 The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm.
Application : WB
Reactivity : Human
Sukhodolets KE et al. Mol Cell Biol 2003; 23 (2):493-509 The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene.
Application : ICC/IF
Agarwal SK et al. Proc Natl Acad Sci U S A 2003; 100 (19):10770-5 Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter.
Application : WB
Jaubert J et al. Development 2003; 130 (12):2767-77 Ectopic expression of kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier.
Application : WB
Reactivity : Mouse
Sunn KL et al. Mol Endocrinol 2001; 15 (9):1599-609 Novel N-terminal variant of human VDR.
Application : ICC/IF
Reactivity : Monkey
Bounpheng MA et al. Gene 2000; 242 (43102):41-50 Characterization of the mouse JAB1 cDNA and protein.
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