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Nucleophosmin antibody [5A4]

Anti-Nucleophosmin antibody [5A4] used in IHC (Paraffin sections) (IHC-P). GTX01967

Cat. No. GTX01967

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 5A4

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($609)
See all Nucleophosmin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:200

Note :

IHC-P
Heat Induced Epitope Retreival (HIER) was performed in Epitope Retreival Solution pH6.
Not tested in other applications.

Calculated MW

33 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

Prokaryotic recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript (419-520 amino acids).

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

nucleophosmin 1 , B23 , NPM

Cellular Localization

nucleoplasm , Nucleolus

Background

The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]

Database

Research Area

DATA IMAGES

Anti-Nucleophosmin antibody [5A4] used in IHC (Paraffin sections) (IHC-P). GTX01967

GTX01967 IHC-P Image

IHC-P analysis of anaplastic large cell lymphoma using GTX01967 Nucleophosmin antibody [5A4]. Note the strong nuclear and cytoplasmic staining in the neoplastic cells.

REFERENCE

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REVIEW

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Package List Price ($)
$ 609