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Nucleoredoxin antibody [N3C3]

Cat. No. GTX107039

Reference 6

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-Fr, IP

Reactivity

 Human, Mouse
Package
100 μl ($399),
25 μl ($169)
See all Nucleoredoxin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-Fr Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

48 kDa. ( Note )

Predict Reactivity

Rat, Zebrafish, Bovine, Xenopus laevis(>80% identity)

PROPERTIES

Form

Liquid

Buffer

0.1M Tris, 0.1M Glycine, 10% Glycerol

Preservative

0.01% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.79 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human Nucleoredoxin. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_2037559

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

nucleoredoxin , NRX , TRG-4

Cellular Localization

Cytoplasm , cytosol , Nucleus

Background

Functions as a redox-dependent negative regulator of the Wnt signaling pathway. May function as a transcriptional regulator. May regulate phosphatase 2A.

Database

Research Area

REFERENCE

Application Reference

Idelfonso-Garc?a OG et al. Antioxidants (Basel) 2024; 13 (3) Nucleoredoxin Redox Interactions Are Sensitized by Aging and Potentiated by Chronic Alcohol Consumption in the Mouse Liver.
OG Idelfonso-Garc?a et al. Antioxidants? 2024; 13 (1) : 257 Nucleoredoxin Redox Interactions Are Sensitized by Aging and Potentiated by Chronic Alcohol Consumption in the Mouse Liver
Application : WB, IHC-Fr, IP
Jaime Arellanes-Robledo et al. Biochem Pharmacol. 2020; 183 : 114323 Flightless-I is a potential biomarker for the early detection of alcoholic liver disease.
Application : WB
Reactivity : Human, Mouse
Brisa Rodope Alarcón-Sánchez et al. Basic Clin Pharmacol Toxicol. 2020; 127 (5) : 389-404 Nucleoredoxin interaction with flightless-I/actin complex is differentially altered in alcoholic liver disease.
Application : IP
Reactivity : Human, Mouse
Arellanes-Robledo J et al. Biochem Pharmacol 2018; (Epub) Ethanol Targets Nucleoredoxin/Dishevelled Interactions and Stimulates Phosphatidylinositol 4-phosphate Production In vivo and In vitro.
Application : WB
Reactivity : Mouse
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SDS
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 399
$ 169