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OAS1 antibody, N-term

Anti-OAS1 antibody, N-term used in Western Blot (WB). GTX47393
Anti-OAS1 antibody, N-term used in IHC (Paraffin sections) (IHC-P). GTX47393

Cat. No. GTX47393

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human
Package
50 μg ($409)
See all OAS1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.2-2.5 ug/ml
IHC-P 2-10 ug/ml
Not tested in other applications.

Calculated MW

46 kDa. ( Note )

Positive Control

human fetal stomach

PROPERTIES

Form

Liquid

Buffer

PBS, 2% Sucrose

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5-1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A synthetic peptide corresponding to a N-terminal region of Human OAS1

Purification

Affinity Purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

2'-5'-oligoadenylate synthetase 1 , E18/E16 , IFI-4 , OIAS , OIASI

Cellular Localization

Cytoplasm,Mitochondrion,Nucleus,Microsome,Endoplasmic reticulum,Secreted

Background

This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, Feb 2016]

Database

Research Area

DATA IMAGES

Anti-OAS1 antibody, N-term used in Western Blot (WB). GTX47393

GTX47393 WB Image

WB analysis of human fetal stomach tissue using GTX47393 OAS1 antibody at 0.2-1μg/ml.

Anti-OAS1 antibody, N-term used in IHC (Paraffin sections) (IHC-P). GTX47393

GTX47393 IHC-P Image

IHC-P analysis of human small intestine tissue using GTX47393 OAS1 antibody at 5μg/ml.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 409