GeneTex
United States (US)

ODC antibody [3F293]

Cat No. GTX15167

Host Mouse
Clonality Monoclonal
Clone Name 3F293
Isotype IgG1
Application IHC-Fr
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

Not recommended for use in Western blotting. IHC-Fr: Use at an assay dependent dilution. Optimal dilutions/concentrations should be determined by the end user.

Positive Control

Epithelial cells in normal placenta or prostate carcinoma

Specificity/Sensitivity

Recognizes the native ODC and not the inhibited (labeled with H3-DFMO) enzyme.
PROPERTIES

Form

Liquid

Buffer

Preservative: NoneConstituents: 10mM PBS. pH 7.4

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

A synthetic hexadecapeptide (KPDEKYYSSSIWGPTC), corresponding to amino acids 345-360 from rat ODC.

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Cellular Localization

Cytoplasmic

Background

Ornithine Decarboxylase (ODC) is the initial and rate limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.

Research Area

Package List Price ($)
$ 319