OLR1 / LOX-1 antibody [23C11]

Cat. No. GTX54456

Host	Mouse
Clonality	Monoclonal
Clone Name	23C11
Isotype	IgG1
Application	ICC/IF, IHC-P, FACS, Neutralizing/Inhibition
Reactivity	Human, Mouse
Package	50 μg ($399)

See all OLR1 / LOX-1 products

Datasheet

View product citations for antibody GTX54456 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
ICC/IF	Assay dependent
IHC-P	Assay dependent
FACS	10 μg/ml
Neutralizing/Inhibition	Assay dependent
Note : Neutralizing/Inhibition Antibody totally prevented Hsp70 binding to LOX-1-CHO but not mock-transfected CHO cells.

Not tested in other applications.

Calculated MW

31 kDa. ( Note )

Product Note

The monoclonal antibody 23C11 recognizes oxidized low-density lipoprotein receptor-1 (LOX-1). Monoclonal antibody 23C11 neutralizes LOX-1 and inhibits Hsp70 binding to dendritic cells and Hsp70-induced antigen cross-presentation. In vivo, targeting LOX-1 with a tumor antigen using anti-LOX-1 antibody 23C11 induces anti-tumor immunity.

PROPERTIES

Form

Liquid

Buffer

Filter-sterilized PBS, 0.1% BSA

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

100 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Fusion protein of extracellular domain (aa 71-273) of human LOX-1 with murine Fcγ1 (LOX-1-muFc) produced in PEAK cells

Purification

Purified IgG1

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CLEC8A,LOX1,LOXIN,OLR1,SCARE1,SLOX1,oxidized low density lipoprotein receptor 1,LOX-1

Cellular Localization

Cell membrane,Membrane raft,Secreted

Background

This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

Database

Gene ID: 4973 OLR1
UniProt: P78380 OLR1

Research Area

DATA IMAGES

GTX54456 FACS Image

FACS analysis of PBMC cells using GTX54456 OLR1 / LOX-1 antibody [23C11].
Red : Isotype control
Blue : Primary antibody
Dilution : 3 μg/ml

GTX54456 IHC-P Image

IHC-P analysis of human spleen tissue using GTX54456 OLR1 / LOX-1 antibody [23C11].
Dilution : 1:100

REFERENCE

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REVIEW

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Package

List Price ($)

50 μg

$ 399

Qty