*Optimal dilutions/concentrations should be determined by the researcher.
Antibody totally prevented Hsp70 binding to LOX-1-CHO but not mock-transfected CHO cells.
Not tested in other applications.
The monoclonal antibody 23C11 recognizes oxidized low-density lipoprotein receptor-1 (LOX-1). Monoclonal antibody 23C11 neutralizes LOX-1 and inhibits Hsp70 binding to dendritic cells and Hsp70-induced antigen cross-presentation. In vivo, targeting LOX-1 with a tumor antigen using anti-LOX-1 antibody 23C11 induces anti-tumor immunity.
0.2 μm filtered in PBS, 0.1% BSA
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
100 μg/ml (Please refer to the vial label for the specific concentration.)
Fusion protein of extracellular domain (aa 71-273) of human LOX-1 with murine Fcγ1 (LOX-1-muFc) produced in PEAK cells
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
CLEC8A,LOX1,LOXIN,OLR1,SCARE1,SLOX1,oxidized low density lipoprotein receptor 1,LOX-1
Cell membrane,Membrane raft,Secreted
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
GTX54456 FACS Image
FACS analysis of PBMC cells using GTX54456 OLR1 / LOX-1 antibody [23C11].
Red : Isotype control
Blue : Primary antibody
Dilution : 3 μg/ml
GTX54456 IHC-P Image
IHC-P analysis of human spleen tissue using GTX54456 OLR1 / LOX-1 antibody [23C11].
Dilution : 1:100