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OLR1 / LOX-1 antibody [23C11]

Anti-OLR1 / LOX-1 antibody [23C11] used in Flow cytometry (FACS). GTX54456
Anti-OLR1 / LOX-1 antibody [23C11] used in IHC (Paraffin sections) (IHC-P). GTX54456

Cat No. GTX54456

Host

Mouse

Clonality

Monoclonal

Clone Name

23C11

Isotype

IgG1

Application

ICC/IF, IHC-P, FACS, Neutralizing/Inhibition

Reactivity

Human, Mouse
Package
50 μg ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF Assay dependent
IHC-P Assay dependent
FACS 10 μg/ml
Neutralizing/Inhibition Assay dependent

Note :

Neutralizing/Inhibition
Antibody totally prevented Hsp70 binding to LOX-1-CHO but not mock-transfected CHO cells.

Not tested in other applications.

Calculated MW

31 kDa. ( Note )

Product Note

The monoclonal antibody 23C11 recognizes oxidized low-density lipoprotein receptor-1 (LOX-1). Monoclonal antibody 23C11 neutralizes LOX-1 and inhibits Hsp70 binding to dendritic cells and Hsp70-induced antigen cross-presentation. In vivo, targeting LOX-1 with a tumor antigen using anti-LOX-1 antibody 23C11 induces anti-tumor immunity.

PROPERTIES

Form

Liquid

Buffer

0.2 μm filtered in PBS, 0.1% BSA

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

100 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Fusion protein of extracellular domain (aa 71-273) of human LOX-1 with murine Fcγ1 (LOX-1-muFc) produced in PEAK cells

Purification

Purified IgG1

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

CLEC8A,LOX1,LOXIN,OLR1,SCARE1,SLOX1,oxidized low density lipoprotein receptor 1,LOX-1

Cellular Localization

Cell membrane,Membrane raft,Secreted

Background

This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

Database

Research Area

DATA IMAGES

Anti-OLR1 / LOX-1 antibody [23C11] used in Flow cytometry (FACS). GTX54456

GTX54456 FACS Image

FACS analysis of PBMC cells using GTX54456 OLR1 / LOX-1 antibody [23C11].
Red : Isotype control
Blue : Primary antibody
Dilution : 3 μg/ml

Anti-OLR1 / LOX-1 antibody [23C11] used in IHC (Paraffin sections) (IHC-P). GTX54456

GTX54456 IHC-P Image

IHC-P analysis of human spleen tissue using GTX54456 OLR1 / LOX-1 antibody [23C11].
Dilution : 1:100

REFERENCE

There are currently no references for OLR1 / LOX-1 antibody [23C11] (GTX54456). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for OLR1 / LOX-1 antibody [23C11] (GTX54456). Be the first to share your experience with this product.