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ORC1 antibody [7A7]

Cat No. GTX80360

Host

Rat

Clonality

Monoclonal

Clone Name

7A7

Isotype

IgG1

Application

WB, IP

Reactivity

Human
Package
50 μl ($479)

APPLICATION

Application Note

Recommended Starting Dilutions:
For WB: Use at 1:1000
Optimal dilutions should be determined experimentally by the researcher.

Calculated MW

97 kDa. ( Note )

Product Note

Human ORC1

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

ORC1 (hsORC)

Purification

Protein G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

origin recognition complex subunit 1 , HSORC1 , ORC1L , PARC1

Cellular Localization

Nucleus

Background

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Database

Research Area

REFERENCE

There are currently no references for ORC1 antibody [7A7] (GTX80360). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for ORC1 antibody [7A7] (GTX80360). Be the first to share your experience with this product.
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 479