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Optineurin antibody

Anti-Optineurin antibody used in Immunoprecipitation (IP). GTX54617
Anti-Optineurin antibody used in Western Blot (WB). GTX54617
Anti-Optineurin antibody used in IHC (Paraffin sections) (IHC-P). GTX54617

Cat. No. GTX54617

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, IP

Reactivity

 Human, Mouse
Package
100 μl ($399)
See all Optineurin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
IP 1:50 - 1:200
Not tested in other applications.

Calculated MW

66 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-577 of human OPTN (NP_068815.2).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

optineurin , ALS12 , FIP2 , GLC1E , HIP7 , HYPL , NRP , TFIIIA-INTP

Cellular Localization

Golgi apparatus,Cytoplasmic vesicle

Background

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-Optineurin antibody used in Immunoprecipitation (IP). GTX54617

GTX54617 IP Image

IP analysis of mouse heart cell lysate using GTX54617 Optineurin antibody.
Antibody amount : 3μg / 25μg lysate
Dilution : 1:1000

Anti-Optineurin antibody used in Western Blot (WB). GTX54617

GTX54617 WB Image

WB analysis of various sample lysates using GTX54617 Optineurin antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-Optineurin antibody used in IHC (Paraffin sections) (IHC-P). GTX54617

GTX54617 IHC-P Image

IHC-P analysis of human liver cancer tissue using GTX54617 Optineurin antibody.
Dilution : 1:100

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399