GeneTex
United States (US)

P2X3 antibody

P2X3-antibody_IHC_GTX10267-1_19011506_732.jpg
P2X3-antibody_EM_GTX10267-1_19011506_512.jpg

Cat No. GTX10267

Host Guinea pig
Clonality Polyclonal
Isotype IgG
Application IHC-Fr, EM, IHC
Reactivity Rat
APPLICATION

Application Note

IHC-Fr: Use at a dilution of 1/1000. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

44 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Preservative: 0.05% Sodium Azide; Constituents: Whole Serum

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Antiserum

Antigen Species

Rat

Immunogen

Synthetic peptide: VEKQSTDSGAYSIGH, corresponding to amino acids 383-397 of Rat P2X3.

Purification

Whole antiserum

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Purinergic Receptor P2X 3,P2Rx3

Cellular Localization

Plasma membrane

Background

P2X3 is a subunit in the family of ion channels activated by extracellular ATP. It was cloned from rat dorsal root ganglia. P2X3 has two putative transmembrane domains with intracellular N- and C-termini. It can form homomeric channels and heteromeric channels with other members of the family. P2X3 is expressed in nociceptive sensory neurons.

Database

Research Area

DATA IMAGES
P2X3-antibody_IHC_GTX10267-1_19011506_732.jpg

GTX10267 IHC Image

P2X3 staining  in rat dorsal root ganglion

P2X3-antibody_EM_GTX10267-1_19011506_512.jpg

GTX10267 EM Image

Non-petidergic fibers expressing P2X3 receptor for ATP are present in lamina II of the contralateral dorsal horn (arrows). The P2X3-positive fibers are eliminated from the rat dorsal horn ipsilateral to the rhizotomy (arrow heads). Spinal cord segment C6. Scale bar 400 um. P2X3 antibody dilution 1:25000