GeneTex
United States (US)

P2X3 antibody

P2X3-antibody_IHC_GTX10269-1_19011506_463.gif

Cat No. GTX10269

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF, IHC-Fr, IHC
Reactivity Human, Mouse, Rat, Primate
APPLICATION

Application Note

ICC: Use at a dilution of 1/1000. IHC-Fr: Use at a dilution of 1/1000. WB: Use at a dilution of 1/1000. Predicted molecular weight: 47.6 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

44 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Preservative: 0.05% Sodium Azide; Constituents: Whole Serum

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Rat

Immunogen

Synthetic peptide: VEKQSTDSGAYSIGH, corresponding to amino acids 383-397 of C-terminus of Rat P2X3.

Purification

Whole antiserum

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Cellular Localization

Plasma membrane

Background

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.

Database

Research Area

DATA IMAGES
P2X3-antibody_IHC_GTX10269-1_19011506_463.gif

GTX10269 IHC Image

DRG sections double-labeled for ASIC3 (red) and either P2X3 (green, A) or TRPV1 (green, B); double-labeled cells are yellow or orange