GeneTex

  • Country / Location Selection

United States (US)

PAX5 antibody [1EW]

Anti-PAX5 antibody [1EW] used in IHC (Paraffin sections) (IHC-P). GTX01923

Cat. No. GTX01923

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 1EW

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($609)
See all PAX5 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:100

Note :

IHC-P
Heat Induced Epitope Retreival (HIER) was performed in Epitope Retreival Solution pH6.
Not tested in other applications.

Calculated MW

42 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Antigen Species

Human

Immunogen

Recombinant protein corresponding to part of the C-terminus of the human Pax-5 molecule.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

paired box 5 , ALL3 , BSAP

Cellular Localization

Nucleus

Background

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Database

Research Area

DATA IMAGES

Anti-PAX5 antibody [1EW] used in IHC (Paraffin sections) (IHC-P). GTX01923

GTX01923 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX01923 PAX5 antibody [1EW]. Note nuclear staining of B cells.

REFERENCE

There are currently no references for PAX5 antibody [1EW] (GTX01923). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for PAX5 antibody [1EW] (GTX01923). Be the first to share your experience with this product.
Submit a Review
Package List Price ($)
$ 609