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PAX8 antibody [PAX8/1491]

Anti-PAX8 antibody [PAX8/1491] used in Protein Array (Protein Array). GTX34961
Anti-PAX8 antibody [PAX8/1491] used in IHC (Paraffin sections) (IHC-P). GTX34961
Anti-PAX8 antibody [PAX8/1491] used in Western Blot (WB). GTX34961
Anti-PAX8 antibody [PAX8/1491] used in IHC (Paraffin sections) (IHC-P). GTX34961

Cat. No. GTX34961

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 PAX8/1491

Isotype

 IgG2b

Application

 WB, IHC-P, Protein Array

Reactivity

 Human
Package
100 μg ($529)
See all PAX8 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1-2μg/ml
IHC-P 1-2μg/ml for 30 minutes at RT
Protein Array Assay dependent

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

48 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment (around aa 60-261) of human PAX8 protein (exact sequence is proprietary)

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

PAX8 , paired box 8

Cellular Localization

Nucleus

Background

This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]

Database

Research Area

DATA IMAGES

Anti-PAX8 antibody [PAX8/1491] used in Protein Array (Protein Array). GTX34961

GTX34961 Protein Array Image

Analysis of Protein Array containing more than 19,000 full-length human proteins using PAX8 Mouse Monoclonal Antibody (PAX8/1491). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a Monoclonal Antibody to its intended target. A Monoclonal Antibody is considered to specific to its intended target if the Monoclonal Antibody has an S-score of at least 2.5. For example, if a Monoclonal Antibody binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that Monoclonal Antibody to protein X is equal to 29.

Anti-PAX8 antibody [PAX8/1491] used in IHC (Paraffin sections) (IHC-P). GTX34961

GTX34961 IHC-P Image

IHC-P analysis of human renal cell carcinoma tissue using GTX34961 PAX8 antibody [PAX8/1491].

Anti-PAX8 antibody [PAX8/1491] used in Western Blot (WB). GTX34961

GTX34961 WB Image

WB analysis of (A) recombinant PAX8 protein(B) Raji cell lysates using GTX34961 PAX8 antibody [PAX8/1491].

Anti-PAX8 antibody [PAX8/1491] used in IHC (Paraffin sections) (IHC-P). GTX34961

GTX34961 IHC-P Image

IHC-P analysis of human thyroid carcinoma tissue using GTX34961 PAX8 antibody [PAX8/1491].

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 529