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PCDH18 antibody

Anti-PCDH18 antibody used in Western Blot (WB). GTX85299
Anti-PCDH18 antibody used in IHC (Paraffin sections) (IHC-P). GTX85299
Anti-PCDH18 antibody used in IHC (Paraffin sections) (IHC-P). GTX85299

Cat. No. GTX85299

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($419)
See all PCDH18 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 2 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

126 kDa. ( Note )

Positive Control

HepG2 Cell Lysate(GTX27900)

Product Note

At least three isoforms of PCDH18 are known to exist. This antibody is predicted to not cross-react with PCDH12.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

PCDH18 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human PCDH18.The immunogen is located within amino acids 50 - 100 of PCDH18.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

protocadherin 18 , PCDH68L

Cellular Localization

Cell membrane

Background

Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 18 (PCDH18) was initially identified through screening of human and mouse ESTs using conserved cytoplasmic domain motifs. Tissue screening revealed PCDH18 broad expression in tissues such as brain, liver, heart, kidney, lung, and trachea. PCDH18 expression is also temporally and spatially regulated in the mouse embryonic brain and interacts with Disabled-1, an intracellular adapter protein involved in neuronal migration and cell positioning during mammalian brain development. PCDH18 was also found to be expressed in the developing zebrafish neural tube and central nervous system, lending support to the hypothesis that PCDH18 may play a role during brain development. At least three isoforms of PCDH18 are known to exist. This antibody is predicted to not cross-react with PCDH12.

Database

Research Area

DATA IMAGES

Anti-PCDH18 antibody used in Western Blot (WB). GTX85299

GTX85299 WB Image

WB analysis of HepG2 cell lysate in (A) the absence and (B) the presence of blocking peptide using GTX85299 PCDH18 antibody.
Working concentration : 1 μg/ml

Anti-PCDH18 antibody used in IHC (Paraffin sections) (IHC-P). GTX85299

GTX85299 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX85299 PCDH18 antibody.
Working concentration : 20 μg/ml

Anti-PCDH18 antibody used in IHC (Paraffin sections) (IHC-P). GTX85299

GTX85299 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX85299 PCDH18 antibody.
Working concentration : 2.5 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 419