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PCNA antibody

Orthogonal IP/MS
Anti-PCNA antibody used in Immunoprecipitation (IP). GTX100539
Anti-PCNA antibody used in Western Blot (WB). GTX100539
Anti-PCNA antibody used in Western Blot (WB). GTX100539
Anti-PCNA antibody used in IHC (Paraffin sections) (IHC-P). GTX100539
Anti-PCNA antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX100539
Anti-PCNA antibody used in IHC (Paraffin sections) (IHC-P). GTX100539
Anti-PCNA antibody used in IHC (Paraffin sections) (IHC-P). GTX100539
Anti-PCNA antibody used in IHC (Paraffin sections) (IHC-P). GTX100539
Anti-PCNA antibody used in Western Blot (WB). GTX100539
Anti-PCNA antibody used in IHC (Paraffin sections) (IHC-P). GTX100539
Anti-PCNA antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX100539
Anti-PCNA antibody used in Western Blot (WB). GTX100539
Anti-PCNA antibody used in Western Blot (WB). GTX100539
Anti-PCNA antibody used in IHC (Paraffin sections) (IHC-P). GTX100539
Anti-PCNA antibody used in Western Blot (WB). GTX100539
Anti-PCNA antibody used in Western Blot (WB). GTX100539
Anti-PCNA antibody used in Western Blot (WB). GTX100539
Anti-PCNA antibody used in Western Blot (WB). GTX100539

Cat. No. GTX100539

Reference 82
8

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, IHC-Fr, IP, FISH, IHC

Reactivity

 Human, Mouse, Rat, Drosophila, Golden Syrian Hamster
Package
100 μl ($399),
25 μl ($169)
See all PCNA products
PRODUCT

Summary

PCNA antibody recognizes the proliferating cell nuclear antigen (PCNA), a cofactor of DNA polymerase delta with a predicted molecular weight of 29 kDa. PCNA is important for DNA synthesis, repair, and epigenetic modifications, and also serves as an organelle marker of the nucleus. PCNA antibody can be used for distinguishing between early, middle, and late S-phase of the cell cycle as well as grading of different neoplasms.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
IHC-Fr Assay dependent
IP 1:100-1:500
FISH Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

29 kDa. ( Note )

Positive Control

NIH-3T3 , PC-12

Product Note

IP/MS validation was supported by references (PMID:30377373)

Predict Reactivity

Zebrafish, Bovine, Chicken, Pig, Xenopus tropicalis, Rhesus Monkey, Killifish(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 20% Glycerol

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.11 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human PCNA. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_1241163

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

proliferating cell nuclear antigen , ATLD2

Cellular Localization

Nucleus

Background

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-PCNA antibody used in Immunoprecipitation (IP). GTX100539

GTX100539 IP Image

Immunoprecipitation of PCBP2 protein from HeLa whole cell extracts using 5 μg of PCBP2 antibody (GTX100539).
Western blot analysis was performed using PCBP2 antibody (GTX100539).
EasyBlot anti-Rabbit IgG (GTX221666-01) was used as a secondary reagent.

Anti-PCNA antibody used in Western Blot (WB). GTX100539

GTX100539 WB Image

PCNA antibody detects PCNA protein by western blot analysis.
A. 30 μg NIH-3T3 whole cell lysate/extract
12% SDS-PAGE
PCNA antibody (GTX100539) dilution: 1:2500
The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-PCNA antibody used in Western Blot (WB). GTX100539

GTX100539 WB Image

PCNA antibody detects PCNA protein by western blot analysis.
A. 30 μg PC-12 whole cell lysate/extract
12% SDS-PAGE
PCNA antibody (GTX100539) dilution: 1:2500
The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-PCNA antibody used in IHC (Paraffin sections) (IHC-P). GTX100539

GTX100539 IHC-P Image

PCNA antibody detects PCNA protein at nucleus on mouse testis by immunohistochemical analysis.
Sample: Paraffin-embedded mouse testis.
PCNA antibody (GTX100539) dilution: 1:500.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-PCNA antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX100539

GTX100539 ICC/IF Image

PCNA antibody detects PCNA protein at nucleus by immunofluorescent analysis.
Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: PCNA protein stained by PCNA antibody (GTX100539) diluted at 1:500.
Red: Phalloidin, a cytoskeleton marker, diluted at 1:200.
Scale bar = 10 μm.

Anti-PCNA antibody used in IHC (Paraffin sections) (IHC-P). GTX100539

GTX100539 IHC-P Image

PCNA antibody detects PCNA protein at nucleus in human colon by immunohistochemical analysis.
Sample: Paraffin-embedded human colon .
PCNA antibody (GTX100539) diluted at 1:500.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-PCNA antibody used in IHC (Paraffin sections) (IHC-P). GTX100539

GTX100539 IHC-P Image

PCNA antibody detects PCNA protein at nucleus on rat hind brain by immunohistochemical analysis.
Sample: Paraffin-embedded rat hind brain.
PCNA antibody (GTX100539) dilution: 1:500.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-PCNA antibody used in IHC (Paraffin sections) (IHC-P). GTX100539

GTX100539 IHC-P Image

PCNA antibody detects PCNA protein at nucleus in human cervical carcinoma by immunohistochemical analysis.
Sample: Paraffin-embedded human cervical carcinoma.
PCNA antibody (GTX100539) diluted at 1:500.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-PCNA antibody used in Western Blot (WB). GTX100539

GTX100539 WB Image

PCNA antibody detects PCNA protein by Western blot analysis. Various whole cell extracts (30 μg) were separated by 12% SDS-PAGE, and the membrane was blotted with PCNA antibody (GTX100539) diluted at 1:2500.

Anti-PCNA antibody used in IHC (Paraffin sections) (IHC-P). GTX100539

GTX100539 IHC-P Image

PCNA antibody detects PCNA protein at nucleus on mouse testis by immunohistochemical analysis.
Sample: Paraffin-embedded mouse testis.
PCNA antibody (GTX100539) dilution: 1:500.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-PCNA antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX100539

GTX100539 ICC/IF Image

PCNA antibody detects PCNA protein at nucleus by immunofluorescent analysis.
Sample: HeLa cells were fixed in ice-cold MeOH for 5 min.
Green: PCNA protein stained by PCNA antibody (GTX100539) diluted at 1:1000.
Blue: Hoechst 33342 staining.
Scale bar = 10 μm.

Anti-PCNA antibody used in Western Blot (WB). GTX100539

GTX100539 WB Image

Whole cell extract (30 μg) was separated by 12% SDS-PAGE, and the membrane was blotted with PCNA antibody (GTX100539) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-PCNA antibody used in Western Blot (WB). GTX100539

GTX100539 WB Image

Orthogonal

The data was published in the journal Oncotarget in 2017. PMID: 27458161

Anti-PCNA antibody used in IHC (Paraffin sections) (IHC-P). GTX100539

GTX100539 IHC-P Image

The data was published in the journal Sci Rep in 2017. PMID: 28112237

Anti-PCNA antibody used in Western Blot (WB). GTX100539

GTX100539 WB Image

The data was published in the journal Cell Death Dis in 2014.PMID: 25429617

Anti-PCNA antibody used in Western Blot (WB). GTX100539

GTX100539 WB Image

The data was published in the journal Biomolecules in 2019.PMID: 31614639

Anti-PCNA antibody used in Western Blot (WB). GTX100539

GTX100539 WB Image

The data was published in the journal Sci Rep in 2016.PMID: 27659793

Anti-PCNA antibody used in Western Blot (WB). GTX100539

GTX100539 WB Image

The data was published in the journal Toxins (Basel) in 2013. PMID: 24335753

REFERENCE

Application Reference

Wei C et al. J Hypertens 2024; 42 (3) : 420-431 Resolvin D1 attenuates Ang II-induced hypertension in mice by inhibiting the proliferation, migration and phenotypic transformation of vascular smooth muscle cells by blocking the RhoA/mitogen-activated protein kinase pathway.
Zhong X et al. Acta Pharm Sin B 2024; 14 (2) : 712-728 The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3-SRF axis.
M Brzozowa-Zasada et al. Int J Mol Sci 2024; 25 (2) : 1097 Glutathione Reductase Expression and Its Prognostic Significance in Colon Cancer
Application : IHC-P
M Brzozowa-Zasada et al. Int J Mol Sci 2024; 25 (2) : 1060 Glutaredoxin 2 Protein (Grx2) as an Independent Prognostic Factor Associated with the Survival of Colon Adenocarcinoma Patients
Application : IHC-P
M Brzozowa-Zasada et al. Int J Mol Sci 2024; 25 (2) : 1007 A Prognostic Activity of Glutaredoxin 1 Protein (Grx1) in Colon Cancer
Application : IHC-P
Show More +
Submit a Reference

REVIEW

PCNA antibody Cat. No. GTX100539

Rating
( Average 4.3 based on 8 users reviews)
Application
Western Blot(WB)
( Average 4.3 based on 4 users reviews)
Immunocytochemistry/ Immunofluorescence(ICC/IF)
( Average 4 based on 3 users reviews)
IHC (Paraffin sections)(IHC-P)
( Average 5 based on 1 users reviews)
Anti-PCNA antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX100539
Date : Anonymous submitted on 14-Feb-2023
Score :
Application Tested : ICC/IF
Sample Species : Hu
Sample : HEK293 overexpressing PCNA cells
Blocking : 5% non-fat milk in PBST, 25°C, 1Hr
Fixation : 4% PFA
Permeabilization /Antigen retrieval : 0.3% Triton X-100
Primary Antibody : 1:375, 16°C, 4Hr
Anti-PCNA antibody used in Western Blot (WB). GTX100539
Date : Anonymous submitted on 08-Aug-2022
Score :
Application Tested : WB
Sample Species : Hu
Sample : A375 cells
Amount used : 30μg
Blocking : 5% non-fat milk, BSA in TBST, 4°C, 1Hr
Primary Antibody : 1:2500, 4°C, > 12Hr
Anti-PCNA antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX100539
Date : Anonymous submitted on 07-Feb-2022
Score :
Application Tested : ICC/IF
Sample Species : Ms
Sample : WAZ-2T +SA cell line derived fr BALB/c ms mammary tumor
Blocking : 1% BSA in PBS (pH7.6), 22°C, 1Hr
Fixation : 95% methnol
Permeabilization /Antigen retrieval : 0.2% Triton X-100 in PBS (pH7.6), 15min, 4°C
Primary Antibody : 1:100, 4°C, 16Hr
Lane Description :
Red: GTX100539 (Alxa Fluor 568)
Blue: DAPI
Anti-PCNA antibody used in IHC (Paraffin sections) (IHC-P). GTX100539
Date : Anonymous submitted on 21-Oct-2020
Score :
Application Tested : IHC-P
Sample Species : Hu
Sample : normal colon tissue
Fixation : Citrate buffer, 0.3°C
Primary Antibody : 1:500, 4°C, 16Hr
Anti-PCNA antibody used in Western Blot (WB). GTX100539
Date : Anonymous submitted on 01-Oct-2019
Score :
Application Tested : WB
Sample Species : Golden Syrian Hamster
Sample : BHK21 cells
Amount used : 5 μg
Blocking : 2.5% non-fat milk, 25°C, 0.5Hr
Primary Antibody : 1:2000, 4°C, 16Hr
Anti-PCNA antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX100539
Date : Anonymous submitted on 05-Jul-2018
Score :
Application Tested : ICC/IF
Sample Species : Hu
Sample : PANC-1 cells
Blocking : PBS with 2% FBS and 0.4% Triton X-100, 25°C, 0.17Hr
Fixation : 4% paraformaldehyde
Permeabilization /Antigen retrieval : PBS with 2% FBS and 0.4% Triton X-100
Primary Antibody : 1:100, 4°C, 16Hr
Anti-PCNA antibody used in Western Blot (WB). GTX100539
Date : Anonymous submitted on 23-May-2016
Score :
Application Tested : WB
Sample Species : Hu
Sample : HeLa cells
Amount used : 20μg
Blocking : 5% milk in TBST, 25°C, 1Hr
Primary Antibody : 1:1000, 25°C, 2Hr
Anti-PCNA antibody used in Western Blot (WB). GTX100539
Date : Anonymous submitted on 30-Jan-2012
Score :
Application Tested : WB
Sample Species : Hu
Sample : A549 cells,SiHa cells,HeLa cells
Amount used : 10μg
Blocking : 5% milk, 25°C, 1Hr
Primary Antibody : 1:1000, 4°C, 16Hr
Show More +
Submit a Review
Application Reference
Wei C et al. J Hypertens 2024; 42 (3):420-431 Resolvin D1 attenuates Ang II-induced hypertension in mice by inhibiting the proliferation, migration and phenotypic transformation of vascular smooth muscle cells by blocking the RhoA/mitogen-activated protein kinase pathway.
Zhong X et al. Acta Pharm Sin B 2024; 14 (2):712-728 The lysine methyltransferase SMYD2 facilitates neointimal hyperplasia by regulating the HDAC3-SRF axis.
M Brzozowa-Zasada et al. Int J Mol Sci 2024; 25 (2):1097 Glutathione Reductase Expression and Its Prognostic Significance in Colon Cancer
Application : IHC-P
M Brzozowa-Zasada et al. Int J Mol Sci 2024; 25 (2):1060 Glutaredoxin 2 Protein (Grx2) as an Independent Prognostic Factor Associated with the Survival of Colon Adenocarcinoma Patients
Application : IHC-P
M Brzozowa-Zasada et al. Int J Mol Sci 2024; 25 (2):1007 A Prognostic Activity of Glutaredoxin 1 Protein (Grx1) in Colon Cancer
Application : IHC-P
HY Su et al. Ecotoxicol Environ Saf 2023; 269:115776 Prenatal exposure to low-dose di-(2-ethylhexyl) phthalate (DEHP) induces potentially hepatic lipid accumulation and fibrotic changes in rat offspring
Application : IHC-P
Brzozowa-Zasada M et al. Int J Mol Sci 2023; 24 (19) Immunohistochemical Expression of Glutathione Peroxidase-2 (Gpx-2) and Its Clinical Relevance in Colon Adenocarcinoma Patients.
AS Arellano Buendia et al. PeerJ 2023; Antioxidant and anti-inflammatory effects of allicin in the kidney of an experimental model of metabolic syndrome
Brzozowa-Zasada M et al. J Clin Med 2023; 12 (17) Immunohistochemical Expression of Upregulated Gene 4 Protein Expression (URG4/URGCP) and Its Association with 5-Year Survival in Patients with Colon Adenocarcinoma.
Alibardi L et al. J Dev Biol 2023; 11 (3) Immunolocalization of Some Epidermal Proteins and Glycoproteins in the Growing Skin of the Australian Lungfish (Neoceratodus forsteri).
Qiwei Yang et al. Biochem. Mol. Biol. 2023; Bromodomain Containing 9 Regulates Signaling Pathways and Reprograms the Epigenome in Human Uterine Fibroid Cells
Application : WB
Reactivity : Human
Brzozowa-Zasada M et al. Int J Mol Sci 2023; 24 (8) The Clinical Application of Immunohistochemical Expression of Notch4 Protein in Patients with Colon Adenocarcinoma.
Marlena Brzozowa-Zasada et al. 2023; 16 (5):10.3390/ph16050740 Immunohistochemical Expression of Glutathione Peroxidase 1 (Gpx-1) as an Independent Prognostic Factor in Colon Adenocarcinoma Patients
Application : IHC-P
Reactivity : Human
Fang ZM et al. Cell Prolif 2023; 56 (4):e13386 Methyltransferase-like 3 suppresses phenotypic switching of vascular smooth muscle cells by activating autophagosome formation.
Application : WB
Reactivity : Human
Zhang W et al. Oxid Med Cell Longev 2023; 2023:9966355 Tubeimoside I Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating SIRT3.
Application : WB
Reactivity : Mouse, Rat
Nat Genet . 2023; Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis
Application : ICC/IF
Y. Nishikawa et al. Acta Med Kindai Univ 2022; 47 (2):27-38 Human Adipose-derived Stem Cells Induce Cell Senescence in a Keloid Model
Application : IHC-P
Reactivity : Mouse
Thomas FM et al. Asian Pac J Cancer Prev 2022; 23 (8):2863-2871 Modulation of POPDC1 Expression by Phenothiazine and Trifluoperazine Suppress Colon Cancer Growth and Migration.
Application : WB
Reactivity : Human
He Y et al. Clin Epigenetics 2022; 14 (1):101 JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells.
Application : WB
Reactivity : Human
Su YC et al. Front Oncol 2022; 12:834941 5-Methoxytryptophan Sensitizing Head and Neck Squamous Carcinoma Cell to Cisplatitn Through Inhibiting Signal Transducer and Activator of Transcription 3 (STAT3).
Application : WB, IHC-P
Reactivity : Human
Suhaini Sudi et al. Pharmaceuticals (Basel) 2022; 15 (2) Carpaine Promotes Proliferation and Repair of H9c2 Cardiomyocytes after Oxidative Insults.
Application : WB
Reactivity : Rat
Fan Y et al. Cell Death Differ 2022; Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt signaling and intestinal homeostasis.
Application : IHC-Fr
Reactivity : Mouse
Fernando E Garc?a-Arroyo et al. Int J Mol Sci 2021; 22 (5) Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet.
Application : WB
Reactivity : Mouse
Xiaoxi Fan et al. Cancer Cell Int 2021; 21 (1):150 LncRNA-SNHG6 promotes the progression of hepatocellular carcinoma by targeting miR-6509-5p and HIF1A.
Application : WB
Reactivity : Human
Xin Yi et al. Front Cardiovasc Med 2021; 8:692856 The Expression Patterns and Roles of Lysyl Oxidases in Aortic Dissection.
Application : WB
Reactivity : Human
Ya-Hui Chen et al. Cancers (Basel) 2021; 13 (18)
Application : WB
Reactivity : Human
Liya Liu et al. Cancer Cell Int 2021; 21 (1):547 Upregulation of SNTB1 correlates with poor prognosis and promotes cell growth by negative regulating PKN2 in colorectal cancer.
Application : IHC-P
Reactivity : Human
Chen YJ et al. Front Pharmacol 2021; 12:773235 Upregulation of IRF9 Contributes to Pulmonary Artery Smooth Muscle Cell Proliferation During Pulmonary Arterial Hypertension.
Application : WB
Yoon JH et al. Biomed Pharmacother 2021; 144:112271 Protective effect of sargahydroquinoic acid against Aβ25-35-evoked damage via PI3K/Akt mediated Nrf2 antioxidant defense system.
Li T et al. Oxid Med Cell Longev 2021; 2021:4158495 OC-STAMP Overexpression Drives Lung Alveolar Epithelial Cell Type II Senescence in Silicosis.
Application : IHC-P
Reactivity : Rat
Wang LT et al. Cancer Lett 2021; 520:160-171 Phosphorylation of intestine-specific homeobox by ERK1 modulates oncogenic activity and sorafenib resistance.
Application : WB
Reactivity : Mouse
Zhang J et al. Mediators Inflamm 2021; 2021:6611085 Anti-Interleukin-16-Neutralizing Antibody Attenuates Cardiac Inflammation and Protects against Cardiac Injury in Doxorubicin-Treated Mice.
Application : WB
Reactivity : Mouse
Wu YH et al. PLoS Pathog 2021; 17 (3):e1008866 Aerobic glycolysis supports hepatitis B virus protein synthesis through interaction between viral surface antigen and pyruvate kinase isoform M2.
Application : WB
Reactivity : Human
Kase Y et al. Sci Rep 2021; 11 (1):5897 Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression.
Application : IHC-P
Reactivity : Human
Chen X et al. Biomed Pharmacother 2021; 137:111318 Qingda granule attenuates cardiac fibrosis via suppression of the TGF-β1/Smad2/3 signaling pathway in vitro and in vivo.
Application : WB
Reactivity : Rat
Mohamed MT et al. Antioxidants (Basel) 2020; 9 (11) Raspberry Ketones Attenuate Cyclophosphamide-Induced Pulmonary Toxicity in Mice through Inhibition of Oxidative Stress and NF-ΚB Pathway.
Wu S et al. PLoS Genet 2020; 16 (6):e1008799 BRM-SWI/SNF chromatin remodeling complex enables functional telomeres by promoting co-expression of TRF2 and TRF1.
Li M et al. Cancer Manag Res 2020; 12:9159-9171
Application : WB
Reactivity : Human
Meyer AV et al. Front Oncol 2020; 10:554883 Host CD39 Deficiency Affects Radiation-Induced Tumor Growth Delay and Aggravates Radiation-Induced Normal Tissue Toxicity.
Application : IHC-P
Reactivity : Mouse
Chen YH et al. Cancer Manag Res 2020; 12:4645-4665
Application : WB
Reactivity : Human
Rojas-Morales P et al. Free Radic Biol Med 2020; 154:75-83 Protection against renal ischemia and reperfusion injury by short-term time-restricted feeding involves the mitochondrial unfolded protein response.
Application : WB
Reactivity : Rat
Ogawa T et al. Am J Pathol 2020; 190 (3):577-585 Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Regulates Epidermal Keratinization under Psoriatic Skin Inflammation.
Application : IHC-P
Reactivity : Mouse
Chen TQ et al. Int J Biol Sci 2020; 16 (7):1252-1263 EHMT2/G9a Inhibits Aortic Smooth Muscle Cell Death by Suppressing Autophagy Activation.
Application : WB
Reactivity : Human
Dao TTP et al. Inflamm Res 2020; 69 (3):309-319 Igalan from Inula helenium (L.) suppresses the atopic dermatitis-like response in stimulated HaCaT keratinocytes via JAK/STAT3 signaling.
Application : WB
Reactivity : Human
Yang WL et al. Food Funct 2020; 11 (1):824-833 Citrus flavonoids suppress IL-5 and ROS through distinct pathways in PMA/ionomycin-induced EL-4 cells.
Application : WB
Reactivity : Mouse
Garc?a-Arroyo FE et al. Biomolecules 2019; 9 (10) Allopurinol Prevents the Lipogenic Response Induced by an Acute Oral Fructose Challenge in Short-Term Fructose Fed Rats.
Chuang HC et al. Cancer Res 2019; (Epub) MAP4K3/GLK promotes lung cancer metastasis by phosphorylating and activating IQGAP1.
Application : IHC-P
Reactivity : Mouse
Elshaer R et al. Life Sci 2019;:116824 Leflunomide-induced liver injury in mice: Involvement of TLR4 mediated activation of PI3K/mTOR/NF庥B pathway.
Kurniawan AL et al. Food Funct 2019; 10 (7):4113-4123 Alteration in iron efflux affects male sex hormone testosterone biosynthesis in a diet-induced obese rat model.
Application : WB
Reactivity : Rat
Zhang T et al. PLoS Genet 2019; 15 (2):e1007925 Strand break-induced replication fork collapse leads to C-circles, C-overhangs and telomeric recombination.
Application : FISH
Reactivity : Human
Tian YF et al. Am J Cancer Res 2018; 8 (9):1812-1822 Preprogramming therapeutic response of PI3K/mTOR dual inhibitor via the regulation of EHMT2 and p27 in pancreatic cancer.
Application : WB
Reactivity : Human
Sikorski K et al. Nat Methods 2018; 15 (11):909-912 A high-throughput pipeline for validation of antibodies.
Application : IP
Reactivity : Human
Liao CL et al. Anticancer Res 2018; 38 (7):3989-3997 Bisdemethoxycurcumin Suppresses Migration and Invasion of Human Cervical Cancer HeLa Cells via Inhibition of NF--B, MMP-2 and -9 Pathways.
Application : WB
Reactivity : Human
Lee J et al. Redox Biol 2018; 18:43266 Neuroprotection against 6-OHDA toxicity in PC12 cells and mice through the Nrf2 pathway by a sesquiterpenoid from Tussilago farfara.
Application : WB
Reactivity : Rat
Crouzet L et al. Sci Rep 2018; 8 (1):5098 lactobacillus paracasei cncm i-3689 reduces *-resistant enterococcus persistence and promotes bacteroidetes resilience in the gut following antibiotic challenge.
Application : IHC-P
Reactivity : Mouse
Kim SH et al. Biomedicine & Pharmacotherapy 2018; 99:997-1008 Teroxirone suppresses growth and motility of human hepatocellular carcinoma cells.
Application : WB
Reactivity : Human
Li R et al. Cell Death Dis 2018; 9 (2):180 EZH2 inhibits autophagic cell death of aortic vascular smooth muscle cells to affect aortic dissection.
Application : WB
Reactivity : Human
Luo L et al. Chin Med J (Engl) 2018; 131 (4):454-460 Exosomal MicroRNA-10a Is Associated with Liver Regeneration in Rats through Downregulation of EphA4.
Application : IHC-P
Reactivity : Rat
Hsieh MT et al. Oncotarget 2017; 8 (15):24237-24249 Crosstalk between integrin αvβ3 and ERα contributes to thyroid hormone-induced proliferation of ovarian cancer cells.
Application : WB
Reactivity : Human
Gao W et al. Transpl Immunol 2017; (Epub) Adipose-derived mesenchymal stem cells promote liver regeneration and suppress rejection in small-for-size liver allograft.
Application : IHC-P
Reactivity : Rat
Ni YL et al. Apoptosis 2017; (Epub) A potent indolylquinoline alleviates growth of human lung cancer cell tumorspheres.
Application : WB
Reactivity : Human
Chiang SL et al. Sci Rep 2017; 7 (1):6235 preventive effect of * use against cancer progression and occurrence of oral squamous cell carcinoma.
Application : WB
Reactivity : Human
Zhang T et al. EMBO Rep 2017; (Epub) Looping-out mechanism for resolution of replicative stress at telomeres.
Application : FISH
Reactivity : Human
Zimmerer RM et al. Microvasc Res 2017; 112:101-108 CD24+ tumor-initiating cells from oral squamous cell carcinoma induce initial angiogenesis in vivo.
Application : IHC-P
Reactivity : Human
Tsai YC et al. J Nucleic Acids 2017; 2017:8154646 Overexpression of PCNA Attenuates Oxidative Stress-Caused Delay of Gap-Filling during Repair of UV-Induced DNA Damage.
Application : WB
Reactivity : Human
Panic A et al. Sci Rep 2017; 7:41138 Progression-related loss of stromal Caveolin 1 levels fosters the growth of human PC3 xenografts and mediates radiation resistance.
Application : IHC-P
Reactivity : Human
Liu T et al. Mol Med Rep 2016; 13 (3):56128 Autologous adipose tissue-derived mesenchymal stem cells are involved in rat liver regeneration following repeat partial hepatectomy.
Application : IHC-P
Reactivity : Rat
Chen YH et al. Journal of Diabetes Research 2016; 2016:Article ID 1828071 the different effects of * and * on cell death and parp activity in pancreatic nit-1 cells.
Application : WB
Reactivity : Mouse
Altan S et al. Burns 2016; (Epub) dimethyl sulfoxide but not * is efficient for healing in hydrofluoric acid eye burns.
Yang SY et al. Sci Rep 2016; 6:33705 Downregulation of angiotensin type 1 receptor and nuclear factor-κB by sirtuin 1 contributes to renoprotection in unilateral ureteral obstruction.
Application : WB
Yang SY et al. Sci Rep 2016; 6:32787 A low-salt diet increases the expression of renal sirtuin 1 through activation of the ghrelin receptor in rats.
Application : WB
Reactivity : Rat
Lee WY et al. Oncotarget 2015; (Epub) repositioning antipsychotic * for treating colorectal cancer by inhibiting sirtuin 1.
Application : WB
Reactivity : Human
Baldan A et al. J Immunol 2014; 193 (11):5637-48 ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis.
Application : IHC-Fr
Reactivity : Mouse
Chang HY et al. Cell Death Dis 2014; 5:e1540 Combination therapy targeting ectopic ATP synthase and 26S proteasome induces ER stress in breast cancer cells.
Application : WB
Reactivity : Human
May EW et al. Pharmacol Res 2014; (Epub) identification of up- and down-regulated proteins in *-resistant uterine cancer cells: reticulocalbin-1 plays a key role in the development of *-associated resistance.
Application : WB
Reactivity : Human
Tomas J et al. ISME J 2014; Early colonizing Escherichia coli elicits remodeling of rat colonic epithelium shifting toward a new homeostatic state.
Application : WB
Reactivity : Rat
Chiu YS et al. Hepatology 2014; IL-20 and IL-20R1 antibodies protect against liver fibrosis.
Application : IHC-P
Reactivity : Human
Bracht T et al. J Proteome Res 2014; Proteome Analysis of a Hepatocyte-Specific BIRC5 (Survivin)-Knockout Mouse Model during Liver Regeneration.
Application : WB
Reactivity : Mouse
Chang WW et al. Toxins (Basel) 2013; 5 (12):2353-65 an extract of rhodobacter sphaeroides reduces *-induced nephrotoxicity in mice.
Application : WB
Reactivity : Mouse
Tan Q et al. J Biol Chem 2013; 288 (24):17134-44 Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation.
Application : WB
Li CJ et al. Cancer Lett 2012; 319 (2):203-13 synergistic anticancer activity of triptolide combined with * enhances apoptosis in gastric cancer in vitro and in vivo.
Application : IHC
Reactivity : Mouse
Chen MC et al. Innate Immun 2012; 18 (5):685-93 Resveratrol inhibits LPS-induced epithelial-mesenchymal transition in mouse melanoma model.
Application : WB
SDS
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Thimerosal.pdf
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