APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
1:50-1:100 |
Note :
IHC-P
Pretreatment : EDTA Buffer pH 8.0 for 30 min at RT
|
Not tested in other applications.
Positive Control
Lung squamous carcinoma
PROPERTIES
Form
Liquid
Buffer
Tissue culture supernatant
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
Antigen Species
Human
Immunogen
coupled to KLH, Last 19 amino acids at the carboxy-terminus of the human membrane-bound PDL1 polypeptide
Purification
Unpurified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
CD274 molecule , B7-H , B7H1 , PD-L1 , PDCD1L1 , PDCD1LG1 , PDL1
Cellular Localization
Cell membrane
Background
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Database
Research Area
DATA IMAGES
|
GTX03297 IHC-P Image
IHC-P analysis of human squamous lung carcinoma tissue section using GTX03297 PD-L1 antibody [405-9A11].
|
REFERENCE
There are currently no references for PD-L1 antibody [405-9A11] (GTX03297). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for PD-L1 antibody [405-9A11] (GTX03297). Be the first to share your experience with this product.