PD-L1 antibody [H302] HistoMAX™

Optimal staining result of the human TNBC, tissue core no. 7, following the vendor recommended protocol settings.
No staining reaction is observed. The tumour was categorized as CPS Low (<10).

Optimal staining result of human NSCLC, tissue core no. 6, using PD-L1 antibody [H302] HistoMAX™ on Leica Bond III, following the vendor recommended protocol settings.
Distinct membranous reactivity ranging from weak to strong intensity is demonstrated across virtually all tumor cells. Based on this diffuse expression pattern, the tumor is categorized as TPS High (≥50%).

Optimal staining result of human NSCLC, tissue core no. 5, using PD-L1 antibody [H302] HistoMAX™ on Leica Bond III, following the vendor recommended protocol settings.
Distinct membranous reactivity (weak-to-moderate intensity) is observed in approximately 40% of tumor cells. Accordingly, the specimen is categorized as TPS Low (≥1–49%).

Optimal staining result of human tonsil using PD-L1 antibody [H302] HistoMAX™ on Leica Bond III, following the vendor recommended protocol settings.
Distinct punctate membranous reactivity (weak-to-moderate intensity) observed in germinal center macrophages and scattered lymphocytes. Note the high signal-to-noise ratio, with the predominant lymphocyte population remaining non-reactive.

Optimal staining result of human NSCLC, tissue core no. 5, using PD-L1 antibody [H302] HistoMAX™ on Leica Bond III, following the vendor recommended protocol settings.
Distinct membranous reactivity (weak-to-moderate intensity) is observed in approximately 40% of tumor cells. Accordingly, the specimen is categorized as TPS Low (≥1–49%).

Optimal staining result of human tonsil using PD-L1 antibody [H302] HistoMAX™ on Leica Bond III, following the vendor recommended protocol settings.
Distinct punctate membranous reactivity (weak-to-moderate intensity) observed in germinal center macrophages and scattered lymphocytes. Note the high signal-to-noise ratio, with the predominant lymphocyte population remaining non-reactive.

Optimal staining result of human NSCLC, tissue core no. 6, using PD-L1 antibody [H302] HistoMAX™ on Leica Bond III, following the vendor recommended protocol settings.
Distinct membranous reactivity ranging from weak to strong intensity is demonstrated across virtually all tumor cells. Based on this diffuse expression pattern, the tumor is categorized as TPS High (≥50%).

Optimal staining result of the human TNBC, tissue core no. 7, following the vendor recommended protocol settings.
No staining reaction is observed. The tumour was categorized as CPS Low (<10).

IHC-P analysis of human corpus luteum from ovary tissue using GTX639925 PD-L1 antibody [H302] HistoMAX™.
Moderate to strong membranous PD-L1 staining of corpus luteum cells.

IHC-P analysis of human placenta (mature) tissue using GTX639925 PD-L1 antibody [H302] HistoMAX™.
Strong PD-L1 staining of the external membrane of the syncytiotrophoblast.

IHC-P analysis of human colorectal adenocarcinoma (COAD) tissue using GTX639925 PD-L1 antibody [H302] HistoMAX™.
PD-L1 negative colorectal adenocarcinoma surrounded by numerous PD-L1 positive inflammatory cells.

IHC-P analysis of human esophageal adenocarcinoma (EAC) tissue using GTX639925 PD-L1 antibody [H302] HistoMAX™.
PD-L1 negative esophageal adenocarcinoma showing intense PD-L1 positivity of tumor adjacent macrophages.

IHC-P analysis of human thymus tissue using GTX639925 PD-L1 antibody [H302] HistoMAX™.
Moderate to strong PD-L1 staining of thymic epithelial cells. Some macrophages also stain positive.

IHC-P analysis of human oropharyngeal squamous cell carcinoma (OPSCC) tissue using GTX639925 PD-L1 antibody [H302] HistoMAX™.
Strong membranous PD-L1 positivity of the stroma-adjacent (peripheric) tumor cell layers of a squamous cell carcinoma of the pharynx.

IHC-P analysis of human lymph node tissue using GTX639925 PD-L1 antibody [H302] HistoMAX™.
A subset of inflammatory cells stain PD-L1 positive.

IHC-P analysis of human oral cavity squamous cell carcinoma (OCSCC) tissue using GTX639925 PD-L1 antibody [H302] HistoMAX™.
Strong predominantly membranous PD-L1 positivity of all tumor cells of a squamous cell carcinoma of the oral cavity. Some inflammatory cells are also PD-L1 positive.