GeneTex
  • Country / Location Selection

United States (US)

PD-L1 antibody [MSVA-711R] HistoMAX

HistoMAX
Anti-PD-L1 antibody [MSVA-711R] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04362
Anti-PD-L1 antibody [MSVA-711R] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04362
Anti-PD-L1 antibody [MSVA-711R] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04362

Cat. No. GTX04362

Host

Rabbit

Clonality

Monoclonal

Clone Name

MSVA-711R

Isotype

IgG

Application

IHC-P

Reactivity

Human
Package
500 μl ($789),
100 μl ($299)
PRODUCT

Summary

This antibody was validated on 76 different Normal and cancerTissues by IHC-P.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:100-1:200

Note :

IHC-P
Manual staining : Heat-induced antigen retrieval for 5 minutes in an autoclave at 121ºC in pH 9.0 Tris-EDTA-based Target Retrieval Solution buffer. Based on the testing result, the pH 9.0 showed a strongest staining pattern. The pH 7.8 is acceptable but lower pH results in a significant reduction of sensitivity.

This antibody has been validated by Autostainer including Agilent/Dako - Autostainer Link 48 and BOND RX - Leica. The detailed steps by Autostainer please refer to the protocol.

Not tested in other applications.

Calculated MW

33 kDa. ( Note )

Positive Control

Alveolar macrophages, tonsil crypt epithelium and the placental cytotrophoblast show strong, predominantly membranous positivity. Follicle centre macrophages should show at least moderate intensity staining.

Negative Control

Appendix (negative staining of all epithelial cells)

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.05% BSA (Please contact us for sodium azide-free or sodium azide and BSA-free format)

Preservative

0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH-conjugated linear peptide corresponding to human PD-L1

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD274 molecule , B7-H , B7H1 , PD-L1 , PDCD1L1 , PDCD1LG1 , PDL1

Cellular Localization

Cell membrane , Early endosome membrane

Background

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Database

Research Area

DATA IMAGES

Anti-PD-L1 antibody [MSVA-711R] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04362

GTX04362 IHC-P Image

IHC-P analysis of human colorectal adenocarcinoma tissue section using GTX04362 PD-L1 antibody [MSVA-711R] HistoMAX.

Anti-PD-L1 antibody [MSVA-711R] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04362

GTX04362 IHC-P Image

IHC-P analysis of human breast cancer tissue section using GTX04362 PD-L1 antibody [MSVA-711R] HistoMAX.
Breast cancer NST with PD L1 negative tumor cells but intense PD L1 staining in tumor associated inflammatory cells.

Anti-PD-L1 antibody [MSVA-711R] HistoMAX used in IHC (Paraffin sections) (IHC-P). GTX04362

GTX04362 IHC-P Image

IHC-P analysis of human placenta mature tissue section using GTX04362 PD-L1 antibody [MSVA-711R] HistoMAX.

REFERENCE

There are currently no references for PD-L1 antibody [MSVA-711R] HistoMAX (GTX04362). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for PD-L1 antibody [MSVA-711R] HistoMAX (GTX04362). Be the first to share your experience with this product.
Package List Price ($)
$ 789
$ 299