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PD1 antibody [NAT105]

Anti-PD1 antibody [NAT105] used in IHC (Paraffin sections) (IHC-P). GTX20256

Cat. No. GTX20256

Reference 25

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 NAT105

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-P, IHC-Fr, FACS, IP, IHC

Reactivity

 Human, Mouse
Package
500 μl ($429)
See all PD1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-P 1:25-100
IHC-Fr Assay dependent
FACS Assay dependent
IP Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

32 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tris buffer, 1% BSA

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Purification

Unpurified

Conjugation

Unconjugated

RRID

AB_2887573

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

programmed cell death 1 , CD279 , PD-1 , PD1 , SLEB2 , hPD-1 , hPD-l , hSLE1

Cellular Localization

Membrane; Single-pass type I membrane protein

Background

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-PD1 antibody [NAT105] used in IHC (Paraffin sections) (IHC-P). GTX20256

GTX20256 IHC-P Image

IHC-P analysis of human tonsil tissue using GTX20256 PD1 antibody [NAT105].

REFERENCE

Application Reference

Li L et al. Pharmacological Research - Modern Chinese Medicine 2021; 1 A combination therapy of ingredients from TCM for the prevention and treatment of gastric cancer by targeting HER2/ PD-L1.
Zhang S et al. BMC Cancer 2020; 20 (1) : 127 PD-L1 and CD4 are independent prognostic factors for overall survival in endometrial carcinomas.
Application : IHC-P
Reactivity : Human

Clone Reference

Kammerer-Jacquet SF et al. Int J Cancer 2017; 140 (1):142-148 Independent association of PD-L1 expression with noninactivated VHL clear cell renal cell carcinoma-A finding with therapeutic potential.
Bastman JJ et al. J Clin Endocrinol Metab 2016; 101 (7):2863-73 Tumor-Infiltrating T Cells and the PD-1 Checkpoint Pathway in Advanced Differentiated and Anaplastic Thyroid Cancer.
Application : IHC
Reactivity : Human
Li CW et al. Nat Commun 2016; 7:12632 Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity.
Reactivity : Mouse
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REVIEW

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Application Reference
Li L et al. Pharmacological Research - Modern Chinese Medicine 2021; 1 A combination therapy of ingredients from TCM for the prevention and treatment of gastric cancer by targeting HER2/ PD-L1.
Zhang S et al. BMC Cancer 2020; 20 (1):127 PD-L1 and CD4 are independent prognostic factors for overall survival in endometrial carcinomas.
Application : IHC-P
Reactivity : Human
Clone Reference
Kammerer-Jacquet SF et al. Int J Cancer 2017; 140 (1):142-148 Independent association of PD-L1 expression with noninactivated VHL clear cell renal cell carcinoma-A finding with therapeutic potential.
Paulsen EE et al. Clin Lung Cancer 2016; Assessing PDL-1 and PD-1 in Non-Small Cell Lung Cancer: A Novel Immunoscore Approach.
Application : WB, IHC-P
Reactivity : Human
Kaewkangsadan V et al. J Immunol Res 2016; 2016:4757405 Crucial Contributions by T Lymphocytes (Effector, Regulatory, and Checkpoint Inhibitor) and Cytokines (TH1, TH2, and TH17) to a Pathological Complete Response Induced by Neoadjuvant Chemotherapy in Women with Breast Cancer.
Application : IHC-P
Reactivity : Human
Dronca RS et al. JCI Insight 2016; 1 (6) T cell Bim levels reflect responses to anti-PD-1 cancer therapy.
Application : IHC-P
Reactivity : Human
Bastman JJ et al. J Clin Endocrinol Metab 2016; 101 (7):2863-73 Tumor-Infiltrating T Cells and the PD-1 Checkpoint Pathway in Advanced Differentiated and Anaplastic Thyroid Cancer.
Application : IHC
Reactivity : Human
Li CW et al. Nat Commun 2016; 7:12632 Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity.
Reactivity : Mouse
Joseph RW et al. Cancer Immunol Res 2015; 3 (1):18-22 Lichenoid dermatitis in three patients with metastatic melanoma treated with anti-PD-1 therapy.
Mishra V et al. Int J Physiol Pathophysiol Pharmacol 2015; 7 (2):87-97 Differential induction of PD-1/PD-L1 in Neuroimmune cells by drug of abuse.
Szabo K et al. Mediators Inflamm 2014; 2014:631787 The histopathology of labial salivary glands in primary Sjogren's syndrome: focusing on follicular helper T cells in the inflammatory infiltrates.
Application : IHC-P
Reactivity : Human
Cogbill CH et al. Am J Clin Pathol 2014; 142 (1):88-98 Utility of CD279/PD-1 immunohistochemistry in the evaluation of benign and neoplastic T-cell-rich bone marrow infiltrates.
Verstegen RH et al. J Allergy Clin Immunol 2014; 134 (6):1346-1353.e9 Defective B-cell memory in patients with Down syndrome.
Arguello RJ et al. PLoS Negl Trop Dis 2014; 8 (8):e2989 Presence of antigen-experienced T cells with low grade of differentiation and proliferative potential in chronic Chagas disease myocarditis.
Application : IHC-P
Reactivity : Human
Liarski VM et al. Sci Transl Med 2014; 6 (230):230ra46 Cell distance mapping identifies functional T follicular helper cells in inflamed human renal tissue.
Reactivity : Human
Smeltzer JP et al. Clin Cancer Res 2014; 20 (11):2862-72 Pattern of CD14+ follicular dendritic cells and PD1+ T cells independently predicts time to transformation in follicular lymphoma.
Kim JR et al. PLoS One 2013; 8 (12):e82870 Tumor infiltrating PD1-positive lymphocytes and the expression of PD-L1 predict poor prognosis of soft tissue sarcomas.
Application : IHC-P
Reactivity : Human
Kang MJ et al. Transl Oncol 2013; 6 (3):282-9 Tumor-infiltrating PD1-Positive Lymphocytes and FoxP3-Positive Regulatory T Cells Predict Distant Metastatic Relapse and Survival of Clear Cell Renal Cell Carcinoma.
Application : IHC-P
Reactivity : Human
Sznol M et al. Clin Cancer Res 2013; 19 (5):1021-34 Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer.
Sato F et al. Leuk Res 2013; 37 (1):43302 Angioimmunoblastic T-cell lymphoma mice model.
French JD et al. J Clin Endocrinol Metab 2012; 97 (6):E934-43 Programmed death-1+ T cells and regulatory T cells are enriched in tumor-involved lymph nodes and associated with aggressive features in papillary thyroid cancer.
Application : IHC-P
Reactivity : Human
Miyoshi H et al. Am J Clin Pathol 2012; 137 (6):879-89 Clinicopathologic analysis of peripheral T-cell lymphoma, follicular variant, and comparison with angioimmunoblastic T-cell lymphoma: Bcl-6 expression might affect progression between these disorders.
Bruneau J et al. Am J Pathol 2010; 177 (2):570-4 Regulatory T-cell depletion in angioimmunoblastic T-cell lymphoma.
Application : IHC-Fr
Reactivity : Human
Wada N et al. Virchows Arch 2009; 455 (3):285-93 Diffuse large B-cell lymphoma with a high number of epithelioid histiocytes (lymphoepithelioid B-cell lymphoma): a study of Osaka Lymphoma Study Group.
Application : IHC-P
Reactivity : Human
Roncador G et al. Haematologica 2007; 92 (8):1059-66 Expression of two markers of germinal center T cells (SAP and PD-1) in angioimmunoblastic T-cell lymphoma.
SDS
Sodium Azide.pdf
Package List Price ($)
$ 429