GeneTex
United States (US)

PD1 antibody [PDCD1/1410R]

GTX34968_20170712_IHC-P_18121410_885.jpg

Cat No. GTX34968

Host Rabbit
Clonality Monoclonal
Clone Name PDCD1/1410R
Isotype IgG
Application IHC-P
Reactivity Human
APPLICATION

Application Note

IHC-P:1-2ug/ml for 30 minutes at RT.

Calculated MW

32 kDa. ( Note )

Specificity/Sensitivity

PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Human recombinant PDCD1 protein fragment (exact sequence is proprietary)

Purification

Ab purified by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Programmed Cell Death 1,Cd279,Pd-1,Pd1,Sleb2,Hpd-1,Hpd-L,Hsle1,Pdcd1

Background

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
GTX34968_20170712_IHC-P_18121410_885.jpg

GTX34968 IHC-P Image

Formalin-fixed, paraffin-embedded human Tonsil stained with PD1 (CD279) Recombinant Rabbit Monoclonal Antibody (PDCD1/1410R).