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PD1 antibody [RMP1-30]

Cat. No. GTX42141

Reference 2

Host

 Rat

Clonality

 Monoclonal

Clone Name

 RMP1-30

Isotype

 IgG2b

Application

 FACS, Functional Assay

Reactivity

 Mouse
Package
500 μg ($399)
See all PD1 products
PRODUCT

Summary

The RMP1-30 antibody is specific for mouse CD279, also known as programmed death-1 (PD-1), a 55 kDa glycoprotein member of the Ig superfamily of molecules. PD-1 exists in a monomeric form that is expressed by CD4- CD8- thymocytes, where it participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-1 expression is also inducible upon activation of mature T cells, where it has been proposed to interact with the co-stimulatory receptor CD80 to limit T cell activation. Two ligands for PD-1, known as PD-L1 (B7-H1) and PD-L2 (B7-DC) are differentially expressed on T and B cells, monocytes, macrophages, NK cells or dendritic cells.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
FACS Assay dependent
Functional Assay Assay dependent
Not tested in other applications.

Calculated MW

32 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

10mM NaH₂PO₄, 150mM NaCl

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

PD-1 transferred BHK cells.

Purification

Purified by affinity chromatography
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

programmed cell death 1 , Ly101 , PD-1 , Pdc1

Cellular Localization

Membrane; Single-pass type I membrane protein

Database

Research Area

REFERENCE

Clone Reference

2017; T-cell-dependent mechanisms promote Ebola VLP-induced antibody responses, but are dispensable for vaccine-mediated protection
Application : FACS
Reactivity : Mouse
2004; B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism
Application : Functional Assay
Reactivity : Mouse
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399