Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Recommended Dilution |
1:200 |
1:10000 |
Assay dependent |
1:100-1:150 |
1:10000 |
1:100-1:150 |
Not tested in other applications.
Calculated MW
Product Note
This antibody has no cross-reactivity against any other PDE family members tested so far. This antibody will detect all PDE10A variants and subtypes.
Form
Liquid
Buffer
Tris/Glycine, 0.5% BSA, 30% Glycerol
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.7 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic peptide (Human) taken against a common sequence near the 250-325 amino acids downstream of N-terminal region of PDE10A. Synthetic MAP.
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Synonyms
phosphodiesterase 10A , ADSD2 , HSPDE10A , IOLOD , LINC00473 , PDE10A19
Cellular Localization
Cytoplasm
Background
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]
Database
Research Area