PDE11A antibody

Cat. No. GTX14623

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, ICC/IF, IP, ELISA, IHC
Reactivity	Human, Mouse, Rat
Package	100 μg ($409)

See all PDE11A products

Datasheet

View product citations for antibody GTX14623 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1:500
ICC/IF	1:250
IP	1:250
ELISA	1:10000
IHC	1:250

Not tested in other applications.

Calculated MW

105 kDa. ( Note )

Product Note

This antibody does not cross-react with any of the members of the PDE family. This antibody is common to all PDE11A variants including PDE11A1-PDE11A4.

PROPERTIES

Form

Liquid

Buffer

Tris/Glycine, 0.5% BSA, 30% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.68 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide taken within amino acid region 100-150 on PDE11A protein, common to all PDE11A variants.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

phosphodiesterase 11A , PPNAD2

Cellular Localization

Cytoplasm, cytosol

Background

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Gene ID: 50940 PDE11A
UniProt: Q9HCR9 PDE11A

Research Area

DATA IMAGES

GTX14623 WB Image

WB analysis of PDE11A recombinant protein using GTX14623 PDE11A antibody.
Dilution : 1:250

GTX14623 IHC Image

IHC analysis of human ovarian medulla tissue using GTX14623 PDE11A antibody.
Dilution : 1:200

REFERENCE

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REVIEW

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Package

List Price ($)

100 μg

$ 409

Qty