GeneTex
United States (US)

PDE11A antibody

PDE11A-antibody_WB_GTX14623-1_18121411_414.jpg

Cat No. GTX14623

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IP
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

IP: Use at a dilution of 1/250. WB: Use at a dilution of 1/500. Detects a bands corresponding to at least three PDE11A variants (approximately 57, 65 and 80 kDa). Optimal dilutions/concentrations should be determined by the end user.

Positive Control

Rat testis, skeletal muscle, kidney and brain

Specificity/Sensitivity

This antibody does not cross-react with any of the members of the PDE family tested so far.
PROPERTIES

Form

Liquid

Buffer

'Stabilization buffer' with 0.02% thimerosal or merthiolate.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.7-0.75 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide (Human) (N terminal).

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Phosphodiesterase 11A,Ppnad2,Pde11A

Background

One of the many phosphodiesterases that compartmentalize and hydrolyze cAMP and cGMP into AMP and GMP is Phosphodiesterase type 11. The human PDE11A contains an open reading frame encoding a 490 amino acid protein (55-56 kDa). The PDE11A has an N-terminus GAF domain homologous to other signaling molecule as found in PDE2, PDE5, PDE6, PDE10, which potentially represents an allosteric cGMP and other small signaling molecules. PDE11A hydrolyzes both cGMP and cAMP; it is sensitive to non-selective PDE inhibitor IBMX as well as zaprinast and dipyrimadole inhibitors that are generally selective for cGMP-specific enzymes. PDE11A expression is diverse and is found in high levels in skeletal muscle, prostate, kidney, liver, pituitary and testis.
DATA IMAGES
PDE11A-antibody_WB_GTX14623-1_18121411_414.jpg

GTX14623 WB Image

Western blot of PC-PD11 with anti PD11 antibodies. 1. GTX14623 1:500 dilution 2. GTX14624 1:500 dilution

Package List Price ($)
$ 329