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PDE11A antibody

KO/KD
Anti-PDE11A antibody used in Western Blot (WB). GTX14624
Anti-PDE11A antibody used in Western Blot (WB). GTX14624
Anti-PDE11A antibody used in Western Blot (WB). GTX14624

Cat. No. GTX14624

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IP, ELISA, IHC

Reactivity

 Human, Mouse, Rat
Package
100 μg ($409)
See all PDE11A products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500
ICC/IF 1:250
IP 1:250
ELISA 1:10000
IHC 1:250
Not tested in other applications.

Calculated MW

105 kDa. ( Note )

Product Note

This antibody does not cross-react with any of the members of the PDE family. This antibody is common to all PDE11A variants including PDE11A1-PDE11A4.

PROPERTIES

Form

Liquid

Buffer

Tris/Glycine, 0.5% BSA, 30% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.68 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide conjugated to KLH, corresponding to C terminal amino acids 454-468 of human PDE11A.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_369849

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

phosphodiesterase 11A , PPNAD2

Cellular Localization

Cytoplasm, cytosol

Background

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-PDE11A antibody used in Western Blot (WB). GTX14624

GTX14624 WB Image

WB analysis of PDE11A recombinant protein using GTX14624 PDE11A antibody.

Anti-PDE11A antibody used in Western Blot (WB). GTX14624

GTX14624 WB Image

WB analysis of PDE11A recombinant protein using GTX14624 PDE11A antibody.
Dilution : 1:250

Anti-PDE11A antibody used in Western Blot (WB). GTX14624

GTX14624 WB Image

KO/KD

WB analysis of PDE11A overexpressed 293T cells with or without shRNA using GTX14624 PDE11A antibody.
Dilution : 1:500

REFERENCE

Application Reference

Azevedo MF et al. J Clin Endocrinol Metab 2013; 98 (8) : E1393-400 Cyclic AMP and c-KIT signaling in familial testicular germ cell tumor predisposition.
Application : IHC
Reactivity : Human
Submit a Reference

REVIEW

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Package List Price ($)
$ 409