GeneTex
United States (US)

PDE2A antibody

PDE2A-antibody_WB_GTX14605-1_18121411_721.jpg
PDE2A-antibody_ICCIF_GTX14605-1_18121411_356.png

Cat No. GTX14605

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF, IP, ELISA, IHC
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

Recommended Starting Dilutions:
For WB: Use at a dilution of 1:250-1:1000.
For IHC: Use at a dilution of 1:250-1:1000.
For ICC/IF: Use at a dilution of 1:250-1:1000.
For IP: Use at a dilution of 1:200.
For ELISA: Use at a dilution of 1:10000.
Optimal dilution should be determined by the end user.

Calculated MW

106 kDa. ( Note )

Positive Control

Rat brain
PROPERTIES

Form

Liquid

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.7 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The immunogen corresponding to a region within amino acids 909 and 926 of human PDE2A.

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Phosphodiesterase 2A,Cgs-Pde,Pde2A1,Ped2A4,Cgspde,Pde2A

Cellular Localization

Cell Membrane

Background

Cyclic nucleotides are important intracellular second messengers which play an important role in a variety of signal transduction process. The cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodiesterases. One of the many phosphodiesterases that compartmentalize and hydrolyze cAMP and cGMP into AMP and GMP is PDE2. Two genes, PDE2A and PDE2B, have been identified and cloned and they both have an apparent molecular weight of 100 kDA. PDE2A has specificity for cAMP and its activity is modulated by the presence of cGMP. In contrast, PDE2B does not hydrolyze cGMP nor its activity is altered by the presence of cGMP. Western blot analyses of PDE2A reveals that it is present in a variety of tissues including neocortex, cerebellum, heart, kidney lungs, pulmonary artery and skeletal muscle.

Database

Research Area

DATA IMAGES
PDE2A-antibody_WB_GTX14605-1_18121411_721.jpg

GTX14605 WB Image

Western blot using GTX14604 in antibody dilution buffer

PDE2A-antibody_ICCIF_GTX14605-1_18121411_356.png

GTX14605 ICC/IF Image

Immunostaining of PDE2A expressing cells with GTX14604 (Ab dilution 1:250)

REFERENCE
Package List Price ($)
$ 329