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PDE4A antibody

Anti-PDE4A antibody used in IHC (Frozen sections) (IHC-Fr). GTX14607
Anti-PDE4A antibody used in Western Blot (WB). GTX14607
Anti-PDE4A antibody used in IHC (Paraffin sections) (IHC-P). GTX14607
Anti-PDE4A antibody used in IHC (Frozen sections) (IHC-Fr). GTX14607
Anti-PDE4A antibody used in IHC (Paraffin sections) (IHC-P). GTX14607
Anti-PDE4A antibody used in IHC (Frozen sections) (IHC-Fr). GTX14607

Cat. No. GTX14607

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, IHC-Fr, IP, ELISA

Reactivity

 Human, Mouse, Rat, Moose
Package
100 μg ($479)
See all PDE4A products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1000-1:2500
ICC/IF 1:100-1:400
IHC-P 1:100-1:400
IHC-Fr 1:100-1:400
IP 1:250
ELISA 1:10000
Not tested in other applications.

Calculated MW

98 kDa. ( Note )

Product Note

This antibody labels all known PDE4A variants including PDE4A1 (66 kDa), PDE4A5 (109 kDa), PDE4A8 (106 kDa), AND PDE4Ax (10 kDa) and a 76 kDa testis specific A variant.

PROPERTIES

Form

Liquid

Buffer

Tris/Glycine, 0.5% BSA, 30% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic cyclic peptide corresponding to the C-terminal region of PDE4A. Common to all PDE4A proteins.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

phosphodiesterase 4A , DPDE2 , PDE4 , PDE46

Cellular Localization

Membrane

Background

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Database

Research Area

DATA IMAGES

Anti-PDE4A antibody used in IHC (Frozen sections) (IHC-Fr). GTX14607

GTX14607 IHC-Fr Image

IHC-Fr analysis of rat seminiferous tubule tissue using GTX14607 PDE4A antibody. PDE4A variants localize exclusively in germ cells.

Anti-PDE4A antibody used in Western Blot (WB). GTX14607

GTX14607 WB Image

WB analysis of PDE4A recombinant protein using GTX14607 PDE4A antibody.
Dilution : 1:500

Anti-PDE4A antibody used in IHC (Paraffin sections) (IHC-P). GTX14607

GTX14607 IHC-P Image

IHC-P analysis of rat kidney tissue using GTX14607 PDE4A antibody.
Dilution : 1:100

Anti-PDE4A antibody used in IHC (Frozen sections) (IHC-Fr). GTX14607

GTX14607 IHC-Fr Image

IHC-Fr analysis of rat seminefrous tubule tissue using GTX14607 PDE4A antibody.

Anti-PDE4A antibody used in IHC (Paraffin sections) (IHC-P). GTX14607

GTX14607 IHC-P Image

IHC-P analysis of human ovarian medulla tissue using GTX14607 PDE4A antibody.
Dilution : 1:15000

Anti-PDE4A antibody used in IHC (Frozen sections) (IHC-Fr). GTX14607

GTX14607 IHC-Fr Image

IHC-Fr analysis of thick section of mouse nose tissue using GTX14607 PDE4A antibody.
Red : Primary antibody
Green : Olfactory sensory neurons

REFERENCE

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REVIEW

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Package List Price ($)
$ 479