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PDE4A8 antibody

Anti-PDE4A8 antibody used in IHC (Frozen sections) (IHC-Fr). GTX14606
Anti-PDE4A8 antibody used in Western Blot (WB). GTX14606

Cat. No. GTX14606

Reference 2

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-Fr, ELISA

Reactivity

 Mouse, Rat
Package
100 μg ($429)
See all PDE4A8 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1000
ICC/IF 1:200
IHC-Fr Assay dependent
ELISA 1:10000
Not tested in other applications.

Calculated MW

98 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tris/Glycine, 0.5% BSA, 30% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.00-1.25 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide specific only for PDE4A8 protein.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_372722

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

phosphodiesterase 4A , DPDE2 , PDE4 , PDE46

Cellular Localization

Membrane

Background

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Database

Research Area

DATA IMAGES

Anti-PDE4A8 antibody used in IHC (Frozen sections) (IHC-Fr). GTX14606

GTX14606 IHC-Fr Image

IHC-Fr analysis of rat seminiferous tubule tissue using GTX14606 PDE4A8 antibody.

Anti-PDE4A8 antibody used in Western Blot (WB). GTX14606

GTX14606 WB Image

WB analysis of rat testis tissue lysate using GTX14606 PDE4A8 antibody.
Dilution : 1:500

REFERENCE

Application Reference

Wilson NM et al. Front Syst Neurosci 2016; 10 : 5 Traumatic Brain Injury Upregulates Phosphodiesterase Expression in the Hippocampus.
Application : WB
Reactivity : Rat
Oliva AA Jr et al. J Neurochem 2012; 123 (6) : 1019-29 Phosphodiesterase isoform-specific expression induced by traumatic brain injury.
Application : WB
Reactivity : Rat
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Package List Price ($)
$ 429