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PDE4B antibody

Anti-PDE4B antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX14611
Anti-PDE4B antibody used in IHC (Frozen sections) (IHC-Fr). GTX14611
Anti-PDE4B antibody used in Western Blot (WB). GTX14611
Anti-PDE4B antibody used in IHC (Paraffin sections) (IHC-P). GTX14611

Cat. No. GTX14611

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, IHC-Fr, IP, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($429)
See all PDE4B products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:1000
ICC/IF 1:250
IHC-P 1:250
IHC-Fr 1:250
IP 1:350
ELISA 1:10000
Not tested in other applications.

Calculated MW

83 kDa. ( Note )

Product Note

This antibody detects all PDE4B proteins, including PDE4B1, PDE4B2, PDE4B3, and a 66 kDa PDE4B variant. It does not cross-react with other PDE family members such as PDE4A, PDE4C. And it may have minor crossreactivity to PDE4D.

PROPERTIES

Form

Liquid

Buffer

Tris/Glycine, 0.5% BSA, 30% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.68 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

Synthetic peptide common to all PDE4B subtypes taken near N-terminal

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

phosphodiesterase 4B , DPDE4 , PDEIVB

Background

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Database

Research Area

DATA IMAGES

Anti-PDE4B antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX14611

GTX14611 ICC/IF Image

ICC/IF analysis of SH-SY5Y cells using GTX14611 PDE4B antibody.
Dilution : 1:250

Anti-PDE4B antibody used in IHC (Frozen sections) (IHC-Fr). GTX14611

GTX14611 IHC-Fr Image

IHC-Fr analysis of seminiferous tubule tissue using GTX14611 PDE4B antibody.

Anti-PDE4B antibody used in Western Blot (WB). GTX14611

GTX14611 WB Image

WB analysis of recombinant PDE4B3 protein(1 and 2), and rat testis tissue (3) lysates using GTX14611 PDE4B antibody.
Dilution : 1:500

Anti-PDE4B antibody used in IHC (Paraffin sections) (IHC-P). GTX14611

GTX14611 IHC-P Image

IHC-P analysis of human ovarian medulla tissue using GTX14611 PDE4B antibody.
Dilution : 1:300

REFERENCE

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REVIEW

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Package List Price ($)
$ 429