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PDE4D3 antibody

Anti-PDE4D3 antibody used in Western Blot (WB). GTX14614
Anti-PDE4D3 antibody used in Western Blot (WB). GTX14614

Cat. No. GTX14614

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IP, ELISA, IHC

Reactivity

 Mouse, Rat, Chicken
Package
100 μg ($429)
See all PDE4D3 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500
ICC/IF 1:200
IP 1:150
ELISA 1:10000
IHC 1:200
Not tested in other applications.

Calculated MW

91 kDa. ( Note )

Product Note

This antibody does not cross react with PDE4D1, PDE4D2, PDE4D4, PDE4D5. Does not cross react with other PDE family members such as PDE4A, PDE4B or PDE4C.

PROPERTIES

Form

Liquid

Buffer

Tris/Glycine, 0.5% BSA, 30% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.68 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on PDE4D3 variant.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_372720

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

phosphodiesterase 4D , ACRDYS2 , DPDE3 , HSPDE4D , PDE43 , PDE4DN2 , STRK1

Cellular Localization

Apical cell membrane , Cytoplasm , Membrane , Cytoplasm, cytoskeleton

Background

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]

Database

Research Area

DATA IMAGES

Anti-PDE4D3 antibody used in Western Blot (WB). GTX14614

GTX14614 WB Image

WB analysis of mouse prefrontal cortical tissue lysate using GTX14614 PDE4D3 antibody.

Anti-PDE4D3 antibody used in Western Blot (WB). GTX14614

GTX14614 WB Image

WB analysis of PDE4D3 recombinant protein using GTX14614 PDE4D3 antibody.
Dilution : 1:500

REFERENCE

Application Reference

Li YF et al. J Neurosci 2011; 31 (1) : 172-83 Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling.
Application : WB
Reactivity : Mouse
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Package List Price ($)
$ 429