*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
This antibody detects 99 and 89 kDa PDE5A proteins in various tissues. This antibody does not cross-react with other PDE family members.
Tris/Glycine pH 7.4-7.9, 30% glycerol, BSA, 0.02% sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
0.55-0.60 mg/ml (Please refer to the vial label for the specific concentration.)
Synthetic peptide common to all PDE5A variants taken within amino acid region 120-170 on human PDE5A protein.
Purified by affinity chromatography
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
phosphodiesterase 5A , CGB-PDE , CN5A , PDE5
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]