GeneTex
United States (US)

PDE6 gamma antibody

img5509_18121411_589.jpg

Cat No. GTX14627

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

WB: Use at a dilution of 1/500. Detects a band of approximately 11 kDa (predicted molecular weight: 10 kDa). Optimal dilutions/concentrations should be determined by the end user.

Specificity/Sensitivity

This antibody does not cross-react with the other PDE6 subunits or with other PDE family members.
PROPERTIES

Form

Liquid

Buffer

Preservative: 0.02% Sodium Azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) (C terminal).

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Background

Cyclic GMP-phosphodiesterase plays a key role in the normal functioning of retinal rod photoreceptor cells. The enzyme is composed of alpha- and beta-catalytic subunits which are inhibited by 2 identical gamma subunits. The PDE6 gamma subunit has been cloned and sequenced from human retina. The 1,012-bp cDNA had a coding region of 261 bp that was highly homologous to those of the corresponding cDNA from bovine and mouse retinas. Comparison of the deduced amino acid sequences from 3 species indicated evolutionary conservation.

Research Area

DATA IMAGES
img5509_18121411_589.jpg

GTX14627 WB Image


Package List Price ($)
$ 319