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PDE6A antibody

Anti-PDE6A antibody used in Immunohistochemistry (IHC). GTX30751

Cat. No. GTX30751

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IP, ELISA, IHC

Reactivity

 Human, Mouse, Rat
Package
100 μg ($409)
See all PDE6A products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500
ICC/IF 1:250
IP 1:250
ELISA 1:10000
IHC 1:250
Not tested in other applications.

Calculated MW

100 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Tris/Glycine, 0.5% BSA, 30% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.50-0.75 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

Synthetic cyclic peptide common to all PDE6 Alpha variants

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

phosphodiesterase 6A , CGPR-A , PDEA , RP43

Cellular Localization

Cell membrane

Background

This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-PDE6A antibody used in Immunohistochemistry (IHC). GTX30751

GTX30751 IHC Image

IHC analysis of lung tissue using GTX30751 PDE6A antibody.

REFERENCE

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REVIEW

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Package List Price ($)
$ 409