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PDE8A antibody

Orthogonal
Anti-PDE8A antibody used in Western Blot (WB). GTX14619

Cat. No. GTX14619

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IP, ELISA, IHC

Reactivity

 Human, Mouse, Rat, Bovine, Monkey
Package
100 μg ($399)
See all PDE8A products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:2000
ICC/IF 1:250
IP 1:250
ELISA 1:10000
IHC 1:250
Not tested in other applications.

Calculated MW

93 kDa. ( Note )

Product Note

This antibody will label only PDE8A variants. This antibody will not cross react with other PDE family members.

PROPERTIES

Form

Liquid

Buffer

Tris/Glycine, 0.5% BSA, 30% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

Synthetic cyclic peptide from mid-region common to all PDE8A variants.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

phosphodiesterase 8A , HsT19550

Background

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

Database

Research Area

DATA IMAGES

Anti-PDE8A antibody used in Western Blot (WB). GTX14619

GTX14619 WB Image

Orthogonal

WB analysis of non-reduced and heated sample lysates using GTX14619 PDE8A antibody.
Lane 1 : SDS-solubilized PDE8 cytosol fraction
Lane 2 : SDS-solubilized treated-PDE8 cytosol fraction
Lane 3 : SDS-solubilized PDE8 cell membrane fraction

REFERENCE

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REVIEW

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Package List Price ($)
$ 399