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PDP1 antibody

Anti-PDP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX54635
Anti-PDP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX54635
Anti-PDP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX54635
Anti-PDP1 antibody used in Western Blot (WB). GTX54635

Cat. No. GTX54635

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Mouse, Rat
Package
100 μl ($399)
See all PDP1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

61 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 278-537 of human PDP1 (NP_060914.2).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

pyruvate dehyrogenase phosphatase catalytic subunit 1 , PDH , PDP , PDPC , PPM2A , PPM2C

Cellular Localization

Mitochondrion matrix

Background

Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]

Database

Research Area

DATA IMAGES

Anti-PDP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX54635

GTX54635 IHC-P Image

IHC-P analysis of mouse spinal cord tissue using GTX54635 PDP1 antibody.
Dilution : 1:100

Anti-PDP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX54635

GTX54635 IHC-P Image

IHC-P analysis of mouse brain tissue using GTX54635 PDP1 antibody.
Dilution : 1:100

Anti-PDP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX54635

GTX54635 IHC-P Image

IHC-P analysis of rat brain tissue using GTX54635 PDP1 antibody.
Dilution : 1:100

Anti-PDP1 antibody used in Western Blot (WB). GTX54635

GTX54635 WB Image

WB analysis of various sample lysates using GTX54635 PDP1 antibody.
Dilution : 1:1000
Loading : 25μg per lane

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399