PBS with 0.02% sodium azide.
PEN2 antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human PEN2.The immunogen is located within the first 50 amino acids of PEN2.
Purified by antigen-affinity chromatography
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Presenilin enhancer protein2, Gammasecretase subunit PEN2, Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2, PEN2, Gamma secretase subunit PEN 2
PEN2, in addition to presenilin, nicastrin, and APH-1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer’s disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic A