APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 0.5 - 1 μg/mL |
| 2.5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
A20 Cell Lysate(GTX27180)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
PEN2 antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human PEN2.The immunogen is located within the first 50 amino acids of PEN2.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
presenilin enhancer, gamma-secretase subunit , ACNINV2 , MDS033 , MSTP064 , PEN-2 , PEN2
Cellular Localization
Endoplasmic reticulum membrane,Cell membrane,Membrane
Background
PEN2, in addition to presenilin, nicastrin, and APH-1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer’s disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic A
Database
Research Area
DATA IMAGES
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GTX85063 IHC-P Image
IHC-P analysis of rat lung tissue using GTX85063 PEN2 antibody.
Working concentration : 2.5 μg/ml
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GTX85063 IHC-P Image
IHC-P analysis of rat lung tissue using GTX85063 PEN2 antibody.
Working concentration : 20 μg/ml
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GTX85063 WB Image
WB analysis of A-20 cell lysate using GTX85063 PEN2 antibody.
Working concentration : (A) 0.5 and (B) 1 μg/ml
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REFERENCE
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REVIEW
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