GeneTex
United States (US)

PEN2 antibody

GTX85063_499_IHC-P_20180221_18121411_466.jpg
GTX85063_3378_WB_20180221_18121411_855.jpg
GTX85063_1936_IHC-P_20180221_18121411_228.jpg

Cat No. GTX85063

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF, IHC-P, ELISA
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5 - 1 μg/mL
ICC/IF Assay dependent
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

12 kDa kDa. ( Note )

Positive Control

A20 Cell Lysate(GTX27180)
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Concentration

1mg/ml

Antigen Species

Human

Immunogen

PEN2 antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human PEN2.The immunogen is located within the first 50 amino acids of PEN2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Presenilin enhancer protein2, Gammasecretase subunit PEN2, Gamma-secretase subunit PEN-2, Presenilin enhancer protein 2, PEN2, Gamma secretase subunit PEN 2

Background

PEN2, in addition to presenilin, nicastrin, and APH-1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer’s disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic A
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Database

Research Area

DATA IMAGES
GTX85063_499_IHC-P_20180221_18121411_466.jpg

GTX85063 IHC-P Image

IHC-P analysis of rat lung tissue using GTX85063 PEN2 antibody.
Working concentration : 20 μg/ml

GTX85063_3378_WB_20180221_18121411_855.jpg

GTX85063 WB Image

WB analysis of A-20 cell lysate using GTX85063 PEN2 antibody.
Working concentration : (A) 0.5 and (B) 1 μg/ml

GTX85063_1936_IHC-P_20180221_18121411_228.jpg

GTX85063 IHC-P Image

IHC-P analysis of rat lung tissue using GTX85063 PEN2 antibody.
Working concentration : 2.5 μg/ml