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PHOX2B antibody

Anti-PHOX2B antibody used in Western Blot (WB). GTX64506
Anti-PHOX2B antibody used in IHC (Paraffin sections) (IHC-P). GTX64506
Anti-PHOX2B antibody used in IHC (Paraffin sections) (IHC-P). GTX64506

Cat. No. GTX64506

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all PHOX2B products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

32 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human PHOX2B (NP_003915.2).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

paired like homeobox 2B , CCHS , NBLST2 , NBPhox , PMX2B

Cellular Localization

Nucleus

Background

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. [provided by RefSeq, Jul 2016]

Database

Research Area

DATA IMAGES

Anti-PHOX2B antibody used in Western Blot (WB). GTX64506

GTX64506 WB Image

WB analysis of various sample lysates using GTX64506 PHOX2B antibody. The signal was developed with ECL plus-Enhanced.
Dilution : 1:1000
Loading : 25μg per lane

Anti-PHOX2B antibody used in IHC (Paraffin sections) (IHC-P). GTX64506

GTX64506 IHC-P Image

IHC-P analysis of rat kidney tissue using GTX64506 PHOX2B antibody.
Dilution : 1:100

Anti-PHOX2B antibody used in IHC (Paraffin sections) (IHC-P). GTX64506

GTX64506 IHC-P Image

IHC-P analysis of rat liver tissue using GTX64506 PHOX2B antibody.
Dilution : 1:100

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399