APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1 - 2 μg/mL |
| 5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
A431 Cell Lysate(GTX27909) , Mouse Spleen Tissue Lysate(GTX27937) , Rat Spleen Tissue Lysate(GTX27945)
Product Note
At least two isoforms are known to exist; this antibody will only detect the longer isoform. PINK1 antibody will detect the cleaved and uncleaved form of PINK1.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
PINK1 antibody was raised against a 16 amino acid peptide near the amino terminus of human PINK1.The immunogen is located within amino acids 120 - 170 of PINK1.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
PTEN induced kinase 1 , BRPK , PARK6
Cellular Localization
Mitochondrion outer membrane,Mitochondrion inner membrane,Cytoplasm, cytosol
Background
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX31581 IHC-P Image
IHC-P analysis of mouse brain tissue using GTX31581 PINK1 antibody.
Working concentration : 20 μg/ml
Green : Primary antibody
Blue : DAPI
Red : Actin
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GTX31581 WB Image
WB analysis of (A) mouse and (B) rat spleen tissue lysate using GTX31581 PINK1 antibody.
Working concentration : 1 μg/ml
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GTX31581 IHC-P Image
IHC-P analysis of mouse brain tissue using GTX31581 PINK1 antibody.
Working concentration : 5 μg/ml
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GTX31581 WB Image
WB analysis of A431 cell lysate in (A) the absence and (B) the presence of blocking peptide using GTX31581 PINK1 antibody.
Working concentration : 1 μg/ml
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REFERENCE
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REVIEW
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