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PLCG1 (phospho Tyr783) antibody

Anti-PLCG1 (phospho Tyr783) antibody used in IHC (Paraffin sections) (IHC-P). GTX32343
Anti-PLCG1 (phospho Tyr783) antibody used in Western Blot (WB). GTX32343

Cat No. GTX32343

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human, Mouse, Rat
Package
100 μl ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:1000
IHC-P 1:100 - 1:200
Not tested in other applications.

Calculated MW

149 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.42% Potassium phosphate, 0.87% Sodium chloride pH 7.3, 30% glycerol, 0.01% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20º C or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of PLCG1. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

phospholipase C gamma 1 , NCKAP3 , PLC-II , PLC1 , PLC148 , PLCgamma1

Background

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-PLCG1 (phospho Tyr783) antibody used in IHC (Paraffin sections) (IHC-P). GTX32343

GTX32343 IHC-P Image

IHC-P analysis of formalin fixed human lung cancer tissue section using GTX32343 PLCG1 (phospho Tyr783) antibody.
Antigen retrieval : Heat mediated antigen retrieval with sodium citrate buffer (pH 6.0)

Anti-PLCG1 (phospho Tyr783) antibody used in Western Blot (WB). GTX32343

GTX32343 WB Image

WB analysis of pervanadate-treated Jurkat (A), LPS-treated NIH3T3 (B), H2O2-treated PC12 (C) whole cell lysates using GTX32343 PLCG1 (phospho Tyr783) antibody.

REFERENCE

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REVIEW

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Package List Price ($)
$ 319