GeneTex
United States (US)

PMS2 antibody

Cat No. GTX30731

Host Rabbit
Clonality Polyclonal
Application WB
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

For WB: Use at a contcentration of 0.5-4μg/ml. Based on ressearcher’s feedback the antibody also works well in IP and IHC, but has not yet been tested in house. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

96 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.2, containing 30% glycerol, 0.5% BSA and 0.01% thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Synthetic peptide - Surrounding amino acid 864 of human PMS2

Purification

Affinity purified with antigen
From polyclonal serum

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

HNPCC4, PMS2CL, PMSL2

Background

This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq]

Database

Research Area

Package List Price ($)
$ 319