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PPM1A antibody [p6c7]

Anti-PPM1A antibody [p6c7] used in Western Blot (WB). GTX14824

Cat. No. GTX14824

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 p6c7

Isotype

 IgG2b

Application

 WB, ELISA

Reactivity

 Human, Mouse
Package
100 μl ($339)
See all PPM1A products

APPLICATION

Application Note

ELISA: Use at an assay dependent dilution. WB: Use at a dilution of 1/250 - 1/1000. Predicted molecular weight: 42 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

42 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant full length protein (Human).

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

protein phosphatase, Mg2+/Mn2+ dependent 1A , PP2C-ALPHA , PP2CA , PP2Calpha

Cellular Localization

Nucleus , Cytoplasm, cytosol , Membrane

Background

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-PPM1A antibody [p6c7] used in Western Blot (WB). GTX14824

GTX14824 WB Image

Western blot analysis of mouse liver cytosol extract using GTX14824 at a dilution of 1/250. Proteins were visualised using a goat anti-mouse secondary antibody conjugated to HRP and a DAB detection system.

REFERENCE

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 339